Effects of Therapeutic Hypothermia for Neuroprotection from the Viewpoint of Redox Regulation

被引：4
作者：
Nosaka, Nobuyuki [1 ]
Okada, Ayumi [1 ]
Tsukahara, Hirokazu [1 ]
机构：
[1] Okayama Univ, Sch Med Dent & Pharmaceut Sci, Dept Pediat, Okayama 7008558, Japan
来源：
ACTA MEDICA OKAYAMA | 2017年 / 71卷 / 01期
关键词：
post-cardiac arrest syndrome; traumatic brain injury; therapeutic hypothermia; oxidative stress; intensive care; TRAUMATIC BRAIN-INJURY; CARDIAC-ARREST; OXIDATIVE STRESS; MILD HYPOTHERMIA; RAPID INDUCTION; NEONATAL ENCEPHALOPATHY; TEMPERATURE MANAGEMENT; MODERATE HYPOTHERMIA; CEREBROSPINAL-FLUID; CEREBRAL-ISCHEMIA;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Redox regulation has recently been recognized as an important factor in acute illnesses as well as in chronic diseases. It has also become a target for neuroprotection in acute intensive care. Despite its well-known therapeutic effects, therapeutic hypothermia has recently been re-evaluated for its potential use in emergency and critical care medicine. Hypothermia is an undesirable physiological condition that can increase oxidative stress and decrease anti-oxidative potency. However, many studies have shown that under ischemia/reperfusion conditions, therapeutic hypothermia actually suppresses enhanced oxidative stress and maintains or increases anti-oxidative potency. This review provides an overview and outlook for the future of therapeutic hypothermia for neuroprotection from the perspective of redox regulation in patients with post-cardiac arrest syndrome and traumatic brain injury.
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页码：1 / 9
页数：9
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