Reproductive development and function of female rats exposed to di-η-butyl-phthalate (DBP) in utero and during lactation

被引：44

作者：

Guerra, Marina T. ^{[1
]}

Scarano, Wellerson R. ^{[1
]}

de Toledo, Fabiola C. ^{[2
]}

Franci, Janete A. A. ^{[3
]}

Kempinas, Wilma De G. ^{[1
]}

机构：

[1] Sao Paulo State Univ, UNESP, Dept Morphol, Inst Biosci, BR-18618000 Botucatu, SP, Brazil

[2] Univ Estadual Campinas, UNICAMP, Inst Biol, Grad Program Cell & Struct Biol, Sao Paulo, Brazil

[3] Univ Sao Paulo, Sch Dent, Dept Morphol Stomatol & Physiol, Sao Paulo, Brazil

来源：

REPRODUCTIVE TOXICOLOGY | 2010年 / 29卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

Maternal exposure; Di-eta-butyl-phthalate; Female offspring; Reproduction; Uterus; Ovary; Estrous cycle; Sexual behavior; DOSE-DEPENDENT ALTERATIONS; SPRAGUE-DAWLEY RATS; DI(N-BUTYL) PHTHALATE; DI-(2-ETHYLHEXYL) PHTHALATE; LATE-GESTATION; PERINATAL EXPOSURE; DIBUTYL PHTHALATE; GENE-EXPRESSION; HUMAN-MILK; METABOLITES;

D O I：

10.1016/j.reprotox.2009.10.005

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Phthalates are environmental contaminants used in the production of plastics, cosmetics and medical devices. Studies on the effects of phthalates on female reproductive health are particularly sparse and mostly restricted to high-dose exposure in rats. In the present study, pregnant rats were treated with 100 mg/kg-d of di-eta-butyl-phthalate (DBP) or only the vehicle (control group), from GD 12 to GD 20 for evaluation of reproductive outcomes and fetal gonads analysis (F0), and from GD 12 to PND 21 to evaluate reproductive development and function on F1 female offspring. Results showed that all parameters were comparable between groups, although there was a significant increase in the fetal weight after DBP exposure. However, the body weight at birth was normal. Based on these data we can conclude that, in these experimental conditions, DBP did not disturb the reproductive development or function of female rats. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：99 / 105

页数：7

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