On Multivariate Method of Qualitative Analysis of Hodgkin-Huxley Model with Decision Tree Induction

被引:0
作者
Martsenyuk, Vasyl [1 ]
Warwas, Kornel [1 ]
Augustynek, Krzysztof [1 ]
Klos-Witkowska, Aleksandra [1 ]
Karpinskyi, Volodymyr [2 ]
Klymuk, Natalya [3 ]
Mayhruk, Zoryana [3 ]
机构
[1] Univ Bielsko Biala, Dept Comp Sci & Automat, Willowa 2, Bielsko Biala, Poland
[2] Coventry Univ, TechnoCtr, Scanners UK Ltd 3D, Coventry, W Midlands, England
[3] Ternopil State Med Univ, Voli Sq 1, UA-46001 Ternopol, Ternopilska Obl, Ukraine
来源
2016 16TH INTERNATIONAL CONFERENCE ON CONTROL, AUTOMATION AND SYSTEMS (ICCAS) | 2016年
关键词
cell excitability; Hodgkin-Huxley model; qualitative analysis; decision tree induction; data mining; NEURAL EXCITABILITY;
D O I
暂无
中图分类号
TP [自动化技术、计算机技术];
学科分类号
0812 ;
摘要
This paper presents a data mining technique for qualitative analysis of Hodgkin-Huxley model of cell excitability. Such problem cannot be solved analytically. Therefore we apply Monte-Carlo techniques for the generation of model parameters, and use data mining algorithm for classification of learning tuples obtained. As a result we attain a decision tree capable of classifying the excitability depending on the relationship between initial conditions and between rate constants. Details of software development and issues of computational complexity are presented. The software includes the package of Java-classes. An example for classification of excitability of three types is presented
引用
收藏
页码:489 / 494
页数:6
相关论文
共 12 条
[1]  
[Anonymous], P CONC SPEC PROGR CS
[2]   A simple modification of the Hodgkin and Huxley equations explains type 3 excitability in squid giant axons [J].
Clay, John R. ;
Paydarfar, David ;
Forger, Daniel B. .
JOURNAL OF THE ROYAL SOCIETY INTERFACE, 2008, 5 (29) :1421-1428
[3]   Type I membranes, phase resetting curves, and synchrony [J].
Ermentrout, B .
NEURAL COMPUTATION, 1996, 8 (05) :979-1001
[4]   THE LOCAL ELECTRIC CHANGES ASSOCIATED WITH REPETITIVE ACTION IN A NON-MEDULLATED AXON [J].
HODGKIN, AL .
JOURNAL OF PHYSIOLOGY-LONDON, 1948, 107 (02) :165-181
[5]   A QUANTITATIVE DESCRIPTION OF MEMBRANE CURRENT AND ITS APPLICATION TO CONDUCTION AND EXCITATION IN NERVE [J].
HODGKIN, AL ;
HUXLEY, AF .
JOURNAL OF PHYSIOLOGY-LONDON, 1952, 117 (04) :500-544
[6]   Neural excitability, spiking and bursting [J].
Izhikevich, EM .
INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS, 2000, 10 (06) :1171-1266
[7]   Decision-Tree Based Model Analysis for Efficient Identification of Parameter Relations Leading to Different Signaling States [J].
Koch, Yvonne ;
Wolf, Thomas ;
Sorger, Peter K. ;
Eils, Roland ;
Brors, Benedikt .
PLOS ONE, 2013, 8 (12)
[8]  
Lyapandra A.S., 2015, P 2015 IEEE 8 INT C, V2, P688, DOI DOI 10.1109/IDAACS.2015.7341391
[9]   QUALITATIVE ANALYSIS OF THE ANTINEOPLASTIC IMMUNITY SYSTEM ON THE BASIS OF A DECISION TREE [J].
Martsenyuk, V. P. ;
Andrushchak, I. Ye. ;
Gvozdetska, I. S. .
CYBERNETICS AND SYSTEMS ANALYSIS, 2015, 51 (03) :461-470
[10]  
Rinzel J., 1998, METHODS NEURONAL MOD, V2nd