Investigation into the Reaction of 2-Amino-4,5-dimethylthiophene-3-carboxamide with Iso(and Isothio)cyanates under Microwave Irradiation

被引：24
作者：
Davoodnia, Abolghasem [1 ]
Rahimizadeh, Mohammad [2 ]
Atapour-Mashhad, Hoda [1 ]
Tavakoli-Hoseini, Niloofar [1 ]
机构：
[1] Islamic Azad Univ, Fac Sci, Dept Chem, Mashhad Branch, Mashhad, Iran
[2] Ferdowsi Univ Mashhad, Fac Sci, Dept Chem, Mashhad, Iran
来源：
HETEROATOM CHEMISTRY | 2009年 / 20卷 / 06期
关键词：
DERIVATIVES; ROUTE;
D O I：
10.1002/hc.20557
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The reaction of 2-amino-4,5-dimethylthiophene-3-carboxamide with iso(and isothio) cyanates for the synthesis of thieno[2,3-d]pyrimidines has been investigated. The reactions under microwave irradiation in the presence of N, N-dimethyl acetamide as solvent gave 5,6-dimethylthieno[2,3-d]pyrimidine-2,4(1H, 3H)-dione, 5,6-dimethyl-2-thioxo-2,3-dihydrothieno[2,3-d]pyrimidin-4(1H)-one, and 2-arylamino-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-one derivatives. These reactions probably proceed through intermediates 4,5-dimethyl-2-substitutedcarbamothioylaminothiophene-3-carboxamides. Two of these intermediates were isolated. (C) 2009 Wiley Periodicals, Inc. Heteroatom Chem 20:346-349, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20557
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页码：346 / 349
页数：4
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