Effects of Intermittent Energy Restriction Combined with a Mediterranean Diet on Reducing Visceral Adiposity: A Randomized Active Comparator Pilot Study

被引:40
作者
Panizza, Chloe E. [1 ]
Lim, Unhee [1 ]
Yonemori, Kim M. [1 ]
Cassel, Kevin D. [1 ]
Wilkens, Lynne R. [1 ]
Harvie, Michelle N. [2 ]
Maskarinec, Gertraud [1 ]
Delp, Edward J. [3 ]
Lampe, Johanna W. [4 ]
Shepherd, John A. [1 ]
Le Marchand, Loic [1 ]
Boushey, Carol J. [1 ]
机构
[1] Univ Hawaii, Canc Ctr, Honolulu, HI 96813 USA
[2] Manchester Univ Hosp Fdn, Natl Hlth Serv Trust, Prevent Breast Canc Res Unit, Manchester M23 9LT, Lancs, England
[3] Purdue Univ, Sch Elect & Comp Engn, W Lafayette, IN 47907 USA
[4] Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, Seattle, WA 98109 USA
基金
美国国家卫生研究院;
关键词
DASH; East Asian American; intermittent energy restriction; Mediterranean diet; randomized trial; total adiposity; visceral adipose tissue; DISEASE RISK MARKERS; X-RAY ABSORPTIOMETRY; WEIGHT-LOSS; CLINICAL-TRIAL; OBESE WOMEN; HEALTHY; BODY; INTERVENTION; OVERWEIGHT; QUANTIFICATION;
D O I
10.3390/nu11061386
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Intermittent energy restriction combined with a Mediterranean diet (IER+MED) has shown promise to reduce body fat and insulin resistance. In the Multiethnic Cohort Adiposity Phenotype Study, Japanese Americans had the highest visceral adipose tissue (VAT) when adjusting for total adiposity. We conducted this pilot study to demonstrate feasibility and explore efficacy of following IER+MED for 12 weeks to reduce VAT among East Asians in Hawaii. Sixty volunteers (aged 35-55, BMI 25-40 kg/m(2), VAT >= 90 cm(2) for men and >= 80 cm(2) for women) were randomized to IER+MED (two consecutive days with 70% energy restriction and 5 days euenergetic MED) or an active comparator (euenergetic Dietary Approaches to Stop Hypertension (DASH) diet). Participants and clinic staff (except dietitians) were blinded to group assignments. IER+MED had significantly larger reductions in DXA-measured VAT and total fat mass (-22.6 +/- 3.6 cm(2) and -3.3 +/- 0.4 kg, respectively) vs. DASH (-10.7 +/- 3.5 cm(2) and -1.6 +/- 0.4 kg) (p = 0.02 and p = 0.005). However, after adjusting for total fat mass, change in VAT was not statistically different between groups; whereas, improvement in alanine transaminase remained significantly greater for IER+MED vs. DASH (-16.2 +/- 3.8 U/L vs. -4.0 +/- 3.6 U/L, respectively, p = 0.02). Attrition rate was 10%, and participants adhered well to study prescriptions with no reported major adverse effect. Results demonstrate IER+MED is acceptable, lowers visceral and total adiposity among East Asian Americans, and may improve liver function more effectively than a healthful diet pattern. ClinicalTrials.gov Identifier: NCT03639350.
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页数:20
相关论文
共 69 条
[1]   Health Effects of Overweight and Obesity in 195 Countries over 25 Years [J].
Afshin, Ashkan ;
Forouzanfar, Mohammad H. ;
Reitsma, Marissa B. ;
Sur, Patrick ;
Estep, Kara ;
Lee, Alex ;
Marczak, Laurie ;
Mokdad, Ali H. ;
Moradi-Lakeh, Maziar ;
Naghavi, Mohsen ;
Salama, Joseph S. ;
Vos, Theo ;
Abate, Kalkidan H. ;
Abbafati, Cristiana ;
Ahmed, Muktar B. ;
Al-Aly, Ziyad ;
Alkerwi, Ala'a ;
Al-Raddadi, Rajaa ;
Amare, Azmeraw T. ;
Amberbir, Alemayehu ;
Amegah, Adeladza K. ;
Amini, Erfan ;
Amrock, Stephen M. ;
Anjana, Ranjit M. ;
Arnlov, Johan ;
Asayesh, Hamid ;
Banerjee, Amitava ;
Barac, Aleksandra ;
Baye, Estifanos ;
Bennett, Derrick A. ;
Beyene, Addisu S. ;
Biadgilign, Sibhatu ;
Biryukov, Stan ;
Bjertness, Espen ;
Boneya, Dube J. ;
Campos-Nonato, Ismael ;
Carrero, Juan J. ;
Cecilio, Pedro ;
Cercy, Kelly ;
Ciobanu, Liliana G. ;
Cornaby, Leslie ;
Damtew, Solomon A. ;
Dandona, Lalit ;
Dandona, Rakhi ;
Dharmaratne, Samath D. ;
Duncan, Bruce B. ;
Eshrati, Babak ;
Esteghamati, Alireza ;
Feigin, Valery L. ;
Fernandes, Joao C. .
NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (01) :13-27
[2]   Effectiveness of a 12-month randomized clinical trial to increase physical activity in multiethnic postpartum women: Results from Hawaii's Na Mikimiki Project [J].
Albright, Cheryl L. ;
Steffen, Alana D. ;
Wilkens, Lynne R. ;
White, Kami K. ;
Novotny, Rachel ;
Nigg, Claudio R. ;
Saiki, Kara ;
Brown, Wendy J. .
PREVENTIVE MEDICINE, 2014, 69 :214-223
[3]  
[Anonymous], 2005, DIETARY REFERENCE IN, DOI [DOI 10.17226/10490, 10.17226/10490]
[4]  
[Anonymous], CLIN GUID ID EV TREA
[5]  
[Anonymous], FUNDAMENTALS OF CLIN
[6]  
[Anonymous], 2015, CURR EPIDEMIOL REP, DOI DOI 10.1007/S40471-015-0053-5
[7]  
[Anonymous], MAN OV OB AD SYST EV
[8]   A clinical trial of the effects of dietary patterns on blood pressure [J].
Appel, LJ ;
Moore, TJ ;
Obarzanek, E ;
Vollmer, WM ;
Svetkey, LP ;
Sacks, FM ;
Bray, GA ;
Vogt, TM ;
Cutler, JA ;
Windhauser, MM ;
Lin, PH ;
Karanja, N .
NEW ENGLAND JOURNAL OF MEDICINE, 1997, 336 (16) :1117-1124
[9]   DIFFERENCES IN LIPOLYSIS BETWEEN HUMAN SUBCUTANEOUS AND OMENTAL ADIPOSE TISSUES [J].
ARNER, P .
ANNALS OF MEDICINE, 1995, 27 (04) :435-438
[10]   An introduction to modern missing data analyses [J].
Baraldi, Amanda N. ;
Enders, Craig K. .
JOURNAL OF SCHOOL PSYCHOLOGY, 2010, 48 (01) :5-37