Subcellular detection and localization of the drug transporter P-glycoprotein in cultured tumor cells

被引:71
作者
Molinari, A
Calcabrini, A
Meschini, S
Stringaro, A
Crateri, P
Toccacieli, L
Marra, M
Colone, M
Cianfriglia, M
Arancia, G
机构
[1] Ist Super Sanita, Ultrastrutture Lab, I-00161 Rome, Italy
[2] Ist Super Sanita, Immunol Lab, I-00161 Rome, Italy
关键词
D O I
10.2174/1389203023380413
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In vitro studies on the cellular location of P-glycoprotein (Pgp) are reported with the aim to clarify the relationship between its intracellular expression and the multidrug resistance (MDR) level of tumor cells.
引用
收藏
页码:653 / 670
页数:18
相关论文
共 65 条
[1]   Defective acidification in human breast tumor cells and implications for chemotherapy [J].
Altan, N ;
Chen, Y ;
Schindler, M ;
Simon, SM .
JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 187 (10) :1583-1598
[2]  
ARANCIA G, 1988, EUR J CELL BIOL, V47, P379
[3]  
BAICINI N, 1995, EUR J CELL BIOL, V68, P226
[4]  
Berger W, 1997, INT J CANCER, V71, P108, DOI 10.1002/(SICI)1097-0215(19970328)71:1<108::AID-IJC18>3.0.CO
[5]  
2-E
[6]   INTRINSIC MDR-1 GENE AND P-GLYCOPROTEIN EXPRESSION IN HUMAN-MELANOMA CELL-LINES [J].
BERGER, W ;
ELBLING, L ;
MINAIPOUR, M ;
VETTERLEIN, M ;
PIRKER, R ;
KOKOSCHKA, EM ;
MICKSCHE, M .
INTERNATIONAL JOURNAL OF CANCER, 1994, 59 (05) :717-723
[7]  
Bichat F, 1997, ANTICANCER RES, V17, P3393
[8]   Clinical relevance of transmembrane drug efflux as a mechanism of multidrug resistance [J].
Bradshaw, DM ;
Arceci, RJ .
JOURNAL OF CLINICAL ONCOLOGY, 1998, 16 (11) :3674-3690
[9]  
Calcabrini A, 1997, EUR J CELL BIOL, V72, P61
[10]  
CALCAORINI A, 2000, HISTOCHEM J, V32, P59