CD8+lymphocytes/tumour-budding index: an independent prognostic factor representing a 'pro-/anti-tumour' approach to tumour host interaction in colorectal cancer

被引：110

作者：

Lugli, A. ^{[1
]}

Karamitopoulou, E. ^{[2
]}

Panayiotides, I. ^{[2
]}

Karakitsos, P. ^{[3
]}

Rallis, G. ^{[4
]}

Peros, G. ^{[4
]}

Iezzi, G. ^{[5
]}

Spagnoli, G. ^{[5
]}

Bihl, M. ^{[1
]}

Terracciano, L. ^{[1
]}

Zlobec, I. ^{[1
]}

机构：

[1] Univ Basel, Inst Pathol, CH-4031 Basel, Switzerland

[2] Attikon Univ Hosp, Dept Pathol 2, Athens 12464, Greece

[3] Attikon Univ Hosp, Dept Diagnost Cytopathol, Athens 12464, Greece

[4] Attikon Univ Hosp, Dept Surg 4, Athens 12464, Greece

[5] Univ Basel, Inst Surg Res & Hosp Management, CH-4031 Basel, Switzerland

来源：

BRITISH JOURNAL OF CANCER | 2009年 / 101卷 / 08期

关键词：

tumour budding; CD8+lymphocytes; colorectal cancer; prognosis; LYMPH-NODE METASTASIS; MICROSATELLITE INSTABILITY; INFILTRATING LYMPHOCYTES; T-CELLS; BETHESDA GUIDELINES; CURATIVE RESECTION; RECTAL-CANCER; IMMUNE CELLS; CARCINOMA; SURVIVAL;

D O I：

10.1038/sj.bjc.6605318

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BACKGROUND: The tumour-host interaction at the invasive front of colorectal cancer, including the epithelial-mesenchymal transition and its hallmark 'tumour budding', is an important area of investigation in terms of prognosis. The aim of this study was to determine the prognostic impact of a 'pro-/anti-tumour' approach defined by an established 'pro-tumour' (tumour budding) and host-related 'anti-tumour' factor of the adaptive immunological microenvironment (CD8+ lymphocytes). METHODS: Double immunostaining for CK22/CD8 on whole tissue sections (n = 279; Cohort 1) and immunohistochemistry for CD8+ using tissue microarrays (n = 191; Cohort 2) was carried out. Tumour buds, CD8+ and CD8+ T-lymphocytes : tumour buds indices were evaluated per high-power field. RESULTS: In Cohort 1, a low-CD8+/buds index was associated with lymph node metastasis (P < 0.001), vascular invasion (P = 0.009), worse survival in univariate (P < 0.001) and multivariable (P < 0.001) analysis, and furthermore in lymph node-negative patients (P = 0.002). In Cohort 2, the CD8+/buds index was associated with T stage (P < 0.001), N stage (P = 0.041), vascular invasion (P = 0.005) and survival in patients with TNM stage II (P = 0.019), stage III (P = 0.004), and adjuvantly untreated (P = 0.009) and treated patients (P < 0.001). CONCLUSION: The CD8+ lymphocyte : tumour-budding index is an independent prognostic factor in colorectal cancer and a promising approach for a future prognostic score for patients with this disease. British Journal of Cancer (2009) 101, 1382-1392. doi:10.1038/sj.bjc.6605318 www.bjcancer.com Published online 15 September 2009 (C) 2009 Cancer Research UK

引用

页码：1382 / 1392

页数：11

共 40 条

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