Metal-organic frameworks-based nanozymes for combined cancer therapy

被引:125
作者
Ding, Shuai-shuai [1 ,2 ,3 ]
He, Ling [4 ]
Bian, Xiu-wu [1 ,2 ,3 ]
Tian, Gan [1 ,2 ,3 ]
机构
[1] Third Mil Med Univ, Army Med Univ, Affiliated Hosp 1, Inst Pathol, Chongqing 40038, Peoples R China
[2] Third Mil Med Univ, Army Med Univ, Affiliated Hosp 1, Southwest Canc Ctr, Chongqing 40038, Peoples R China
[3] Minist Educ China, Key Lab Tumor Immunopathol, Chongqing 40038, Peoples R China
[4] Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, Chongqing 401331, Peoples R China
基金
中国国家自然科学基金;
关键词
Metal-organic frameworks; Nanozymes; Catalysis; Combined therapy; Tumor microenvironment; HYDROGEN-PEROXIDE; COLORIMETRIC DETECTION; TARGETED STARVATION; TUMOR; MOF; ENZYMES; NANOPARTICLES; GENERATION; BIOREACTOR; PLATFORM;
D O I
10.1016/j.nantod.2020.100920
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Nanomaterials with enzyme-like catalytic activity, named as nanozymes, have aroused wide research interest owing to their striking merits bridging nanotechnology and biology. Metal-organic frameworks (MOFs) are a novel class of porous inorganic-organic hybrid materials made from metal ions/clusters and organic ligands, and have shown great prospect in the construction of novel nanozymes, making the asemerged MOFs-based nanozymes promising candidates for biosensing, biocatalysis, biomedical imaging, and therapeutic applications. In this feature article, we tend to systematically summarize the recent process concerning MOFs-based nanozymes for combined cancer therapy, which emerged as a new trend in clinical oncology in view of the synergistic therapeutic efficacy and reduced side effects originating from different treatments. Firstly, classic kinds of MOFs-based nanozymes are briefly described with representatives for catalysis mechanism analysis. Secondly, general strategies for construction of MOFs-based nanozymes are discussed. Thirdly, recent advances in the application of MOFs-based nanozymes for dual or triple combination of therapeutic modalities have been reviewed in detail with a particular emphasis focusing upon underlying synergistic mechanisms involved in each combination formulation. Finally, current challenges and future perspectives of MOFs-based nanozymes with a view to maximizing their great potential in the research of translational medicine are also discussed. It is highly expected that our demonstration on this evolving area will play a more important role in the field of the personalized nanomedicine in combating cancer. (C) 2020 Elsevier Ltd. All rights reserved.
引用
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页数:25
相关论文
共 134 条
[1]   Metal-Organic Framework-Integrated Enzymes as Bioreactor for Enhanced Therapy against Solid Tumor via a Cascade Catalytic Reaction [J].
Bai, Jing ;
Peng, Chengjia ;
Guo, Liping ;
Zhou, Ming .
ACS BIOMATERIALS SCIENCE & ENGINEERING, 2019, 5 (11) :6207-6215
[2]   Gold nanoparticles in combinatorial cancer therapy strategies [J].
Beik, Jaber ;
Khateri, Maziar ;
Khosravi, Zohreh ;
Kamrava, S. Kamran ;
Kooranifar, Siavash ;
Ghaznavi, Habib ;
Shakeri-Zadeh, Ali .
COORDINATION CHEMISTRY REVIEWS, 2019, 387 :299-324
[3]   Novel Nano-/Micro-Biocatalyst: Soybean Epoxide Hydrolase Immobilized on UiO-66-NH2 MOF for Efficient Biosynthesis of Enantiopure (R)-1, 2-Octanediol in Deep Eutectic Solvents [J].
Cao, Shi-Lin ;
Yue, Dong-Mei ;
Li, Xue-Hui ;
Smith, Thomas J. ;
Li, Ning ;
Zong, Min-Hua ;
Wu, Hong ;
Ma, Yong-Zheng ;
Lou, Wen-Yong .
ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 2016, 4 (06) :3586-3595
[4]   Highly efficient colorimetric detection of cancer cells utilizing Fe-MIL-101 with intrinsic peroxidase-like catalytic activity over a broad pH range [J].
Chen, Daomei ;
Li, Bin ;
Jiang, Liang ;
Duan, Deliang ;
Li, Yizhou ;
Wang, Jiaqiang ;
He, Jiao ;
Zeng, Yanbo .
RSC ADVANCES, 2015, 5 (119) :97910-97917
[5]   Modulating the Biofunctionality of Metal-Organic Framework-Encapsulated Enzymes through Controllable Embedding Patterns [J].
Chen, Guosheng ;
Kou, Xiaoxue ;
Huang, Siming ;
Tong, Linjing ;
Shen, Yujian ;
Zhu, Wangshu ;
Zhu, Fang ;
Ouyang, Gangfeng .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 59 (07) :2867-2874
[6]   Local biomaterials-assisted cancer immunotherapy to trigger systemic antitumor responses [J].
Chen, Qian ;
Chen, Muchao ;
Liu, Zhuang .
CHEMICAL SOCIETY REVIEWS, 2019, 48 (22) :5506-5526
[7]   Intelligent Albumin-MnO2 Nanoparticles as pH-/H2O2-Responsive Dissociable Nanocarriers to Modulate Tumor Hypoxia for Effective Combination Therapy [J].
Chen, Qian ;
Feng, Liangzhu ;
Liu, Jingjing ;
Zhu, Wenwen ;
Dong, Ziliang ;
Wu, Yifan ;
Liu, Zhuang .
ADVANCED MATERIALS, 2016, 28 (33) :7129-+
[8]   A biomimetic cascade nanoreactor for tumor targeted starvation therapy-amplified chemotherapy [J].
Cheng, Hong ;
Jiang, Xue-Yan ;
Zheng, Rong-Rong ;
Zuo, Sheng-Jia ;
Zhao, Lin-Ping ;
Fan, Gui-Ling ;
Xie, Bo-Ru ;
Yu, Xi-Yong ;
Li, Shi-Ying ;
Zhang, Xian-Zheng .
BIOMATERIALS, 2019, 195 :75-85
[9]   Eugenol prevents fMLF-induced superoxide anion production in human neutrophils by inhibiting ERK1/2 signaling pathway and p47phox phosphorylation [J].
Chniguir, Amina ;
Pintard, Coralie ;
Liu, Dan ;
Pham My-Chan Dang ;
El-Benna, Jamel ;
Bachoual, Rafik .
SCIENTIFIC REPORTS, 2019, 9 (1)
[10]   Black Phosphorus and its Biomedical Applications [J].
Choi, Jane Ru ;
Yong, Kar Wey ;
Choi, Jean Yu ;
Nilghaz, Azadeh ;
Lin, Yang ;
Xu, Jie ;
Lu, Xiaonan .
THERANOSTICS, 2018, 8 (04) :1005-1026