M2 as a target to combat influenza drug resistance: what does the evidence say?

被引:12
作者
Wang, Jun [1 ,2 ]
机构
[1] Univ Arizona, Dept Pharmacol & Toxicol, Coll Pharm, Tucson, AZ 85718 USA
[2] Univ Arizona, Inst BIO5, Tucson, AZ 85718 USA
关键词
antiviral; influenza; M2-S31N proton channel; A VIRUS M2; ION-CHANNEL ACTIVITY; WILD-TYPE; PROTON CHANNEL; DUAL INHIBITORS; MUTANT; DERIVATIVES; CONDUCTION; DISCOVERY; PROTEIN;
D O I
10.2217/fvl.15.95
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
[No abstract available]
引用
收藏
页码:1 / 4
页数:4
相关论文
共 23 条
  • [11] Maraviroc: The first of a new class of antiretroviral agents
    MacArthur, Rodger D.
    Novak, Richard M.
    [J]. CLINICAL INFECTIOUS DISEASES, 2008, 47 (02) : 236 - 241
  • [12] Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channel
    Pielak, Rafal M.
    Chou, James J.
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 401 (01) : 58 - 63
  • [13] INFLUENZA-VIRUS M2 PROTEIN HAS ION CHANNEL ACTIVITY
    PINTO, LH
    HOLSINGER, LJ
    LAMB, RA
    [J]. CELL, 1992, 69 (03) : 517 - 528
  • [14] Easily Accessible Polycyclic Amines that Inhibit the Wild-Type and Amantadine-Resistant Mutants of the M2 Channel of Influenza A Virus
    Rey-Carrizo, Matias
    Barniol-Xicota, Marta
    Ma, Chunlong
    Frigole-Vivas, Marta
    Torres, Eva
    Naesens, Lieve
    Llabres, Salome
    Juarez-Jimenez, Jordi
    Luque, Francisco J.
    DeGrado, William F.
    Lamb, Robert A.
    Pinto, Lawrence H.
    Vazquez, Santiago
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2014, 57 (13) : 5738 - 5747
  • [15] 3-Azatetracyclo[5.2.1.15'8.01,5]undecane Derivatives: From Wild-Type Inhibitors of the M2 Ion Channel of Influenza A Virus to Derivatives with Potent Activity against the V27A Mutant
    Rey-Carrizo, Matias
    Torres, Eva
    Ma, Chunlong
    Barniol-Xicota, Marta
    Wang, Jun
    Wu, Yibing
    Naesens, Lieve
    DeGrado, William F.
    Lamb, Robert A.
    Pinto, Lawrence H.
    Vazquez, Santiago
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (22) : 9265 - 9274
  • [16] How to overcome resistance of influenza A viruses against adamantane derivatives
    Scholtissek, C
    Quack, G
    Klenk, HD
    Webster, RG
    [J]. ANTIVIRAL RESEARCH, 1998, 37 (02) : 83 - 95
  • [17] Influenza A virus M2 ion channel activity is essential for efficient replication in tissue culture
    Takeda, M
    Pekosz, A
    Shuck, K
    Pinto, LH
    Lamb, RA
    [J]. JOURNAL OF VIROLOGY, 2002, 76 (03) : 1391 - 1399
  • [18] Discovery of Novel Dual Inhibitors of the Wild-Type and the Most Prevalent Drug-Resistant Mutant, S31N, of the M2 Proton Channel from Influenza A Virus
    Wang, Jizhou
    Ma, Chunlong
    Wang, Jun
    Jo, Hyunil
    Canturk, Belgin
    Fiorin, Giacomo
    Pinto, Lawrence H.
    Lamb, Robert A.
    Klein, Michael L.
    DeGrado, William F.
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (07) : 2804 - 2812
  • [19] Recent Progress in Designing Inhibitors That Target the Drug-Resistant M2 Proton Channels From the Influenza A Viruses
    Wang, Jun
    Li, Fang
    Ma, Chunlong
    [J]. BIOPOLYMERS, 2015, 104 (04) : 291 - 309
  • [20] Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus
    Wang, Jun
    Wu, Yibing
    Ma, Chunlong
    Fiorin, Giacomo
    Wang, Jizhou
    Pinto, Lawrence H.
    Lamb, Robert A.
    Klein, Michael L.
    DeGrado, William F.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (04) : 1315 - 1320