Interactions of the spin-labeled chloroethylnitrosourea SLCNUgly with electrode-supported lipid films

被引：2

作者：

Tacheva, Bilyana ^{[1
]}

Georgieva, Radostina ^{[1
,2
]}

Karabaliev, Miroslav ^{[1
]}

机构：

[1] Trakia Univ, Dept Phys & Biophys, Fac Med, 11 Armeiska, Stara Zagora 6000, Bulgaria

[2] Charite, Inst Transfus Med, Charitepl 1, D-10117 Berlin, Germany

来源：

ELECTROCHIMICA ACTA | 2016年 / 192卷

关键词：

Electrode supported thin lipid films; drug-membrane interactions; nitrosourea; voltammetry; PHYSICOCHEMICAL PROPERTIES; CARBON ELECTRODES; NITROXYL RADICALS; WETTING FILMS; IMPEDANCE; MEMBRANE; DRUGS; PHOSPHATIDYLCHOLINE; CHLORPROMAZINE; PERMEABILITY;

D O I：

10.1016/j.electacta.2016.02.009

中图分类号：

O646 [电化学、电解、磁化学];

学科分类号：

081704 ;

摘要：

The spin-labeled chloroethylnitrosourea containig glycine SLCNUgly is an analogue of the clinically used nitrosourea drug lomustine (1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea, CCNU), showing promising properties and features in vitro as well as in vivo. In this work the interaction of SLCNUgly with a lipid model membrane is investigated. The presented results indicate penetration of the drug in the membranes without causing defects of the lipid structure and reveal the potential of both SLCNUgly and electrode-supported lipid films as models for investigating nitrosourea drugs-membrane interactions. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：439 / 447

页数：9

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