Regulation of Calcium Homeostasis by ER Redox: A Close-Up of the ER/Mitochondria Connection

被引：71

作者：

Chernorudskiy, Alexander L. ^{[1
]}

Zito, Ester ^{[1
]}

机构：

[1] IRCCS Ist Ric Farmacol Mario Negri, Dulbecco Telethon Inst, I-20156 Milan, Italy

来源：

JOURNAL OF MOLECULAR BIOLOGY | 2017年 / 429卷 / 05期

关键词：

redox-regulated calcium signaling; mitochondria-associated membranes; SERCA; IP3R; RyR; DEPENDENT ANION CHANNEL; INTRACELLULAR CA2+ OSCILLATIONS; HIGH-RESOLUTION STRUCTURE; ENDOPLASMIC-RETICULUM; SARCOPLASMIC-RETICULUM; RYANODINE RECEPTOR; CRYSTAL-STRUCTURE; SKELETAL-MUSCLE; RELEASE CHANNEL; DISULFIDE REDUCTASE;

D O I：

10.1016/j.jmb.2017.01.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Calcium signaling plays an important role in cell survival by influencing mitochondria -related processes such as energy production and apoptosis. The endoplasmic reticulum (ER) is the main storage compartment for cell calcium (Ca2+; similar to 60-500 mu M), and the Ca2+ released by the ER has a prompt effect on the homeostasis of the juxtaposed mitochondria. Recent findings have highlighted a close connection between ER redox and Ca2+ signaling that is mediated by Ca2+-handling proteins. This paper describes the redox-regulated mediators and mechanisms that orchestrate Ca2+ signals from the ER to mitochondria. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：620 / 632

页数：13

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