New α-glucosidase inhibitors from marine algae-derived Streptomyces sp OUCMDZ-3434

被引：0
|
作者：
Chen, Zhengbo [1 ]
Hao, Jiejie [1 ]
Wang, Liping [2 ,3 ]
Wang, Yi [1 ]
Kong, Fandong [1 ]
Zhu, Weiming [1 ]
机构：
[1] Ocean Univ China, Key Lab Marine Drugs, Minist Educ China, Sch Med & Pharm, Qingdao 266003, Peoples R China
[2] Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550002, Peoples R China
[3] Chinese Acad Sci, Guiyang 550002, Peoples R China
来源：
SCIENTIFIC REPORTS | 2016年 / 6卷
关键词：
BIOSYNTHESIS; ENTEROCIN; DERIVATIVES;
D O I：
10.1038/srep20004
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Wailupemycins H (1) and I (2) with a new skeleton coupled two 6-(2-phenylnaphthalene-1-yl)pyrane-2-one nuclei to a-CH2-linkage were identified from the culture of Streptomyces sp. OUCMDZ-3434 associated with the marine algae, Enteromorpha prolifera. Compounds 1 and 2 are two new alpha-glucosidase inhibitors with the K-i/IC50 values of 16.8/19.7 and 6.0/8.3 mu M, respectively. In addition, the absolute configurations of wailupemycins D (3) and E (4) are also resolved in this paper for the first time.
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页数：9
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