Transcriptional activation of NAD+-dependent protein deacetylase SIRT1 by nuclear receptor TLX

被引：54

作者：

Iwahara, Naotoshi ^{[1
]}

Hisahara, Shin ^{[1
,2
]}

Hayashi, Takashi ^{[1
,2
]}

Horio, Yoshiyuki ^{[1
]}

机构：

[1] Sapporo Med Univ, Dept Pharmacol, Sapporo, Hokkaido 0608556, Japan

[2] Sapporo Med Univ, Dept Neurol, Sapporo, Hokkaido 0608556, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 386卷 / 04期

关键词：

Orphan nuclear receptor; Deacetylase; Neural precursor cell; Neurogenesis; TLX; SIRT1; Promoter; Transactivator; Repressor; NEURAL STEM-CELLS; HISTONE DEACETYLASE; GENE TAILLESS; DROSOPHILA; DIFFERENTIATION; EXPRESSION;

D O I：

10.1016/j.bbrc.2009.06.103

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An orphan nuclear receptor TLX is a transcriptional repressor that promotes the proliferation and self-renewal of neural precursor cells (NPCs). SIRT1, an NAD(+)-dependent protein deacetylase, is highly expressed in the NPCs and participates in neurogenesis. Here, we found that TLX colocalized with SIRT1 and knockdown of TLX by small interfering RNAs decreased SIRT1 levels in NPCs. TLX increased the SIRT1 expression by binding to the newly identified TLX-activating element in the SIRT1 gene promoter in HEK293 cells. Thus, TLX is an inducer of SIRT1 and may contribute to neurogenesis both as a transactivator and as a repressor. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：671 / 675

页数：5

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