Selective remote C-H sulfonylation of aminoquinolines with arylsulfonyl chlorides via copper catalysis

被引：141
作者：
Liang, Hong-Wen [1 ]
Jiang, Kun [1 ]
Ding, Wei [1 ]
Yuan, Yi [1 ]
Shuai, Li [1 ]
Chen, Ying-Chun [1 ]
Wei, Ye [1 ]
机构：
[1] Third Mil Med Univ, Coll Pharm, Chongqing 400038, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 95期
关键词：
UNSYMMETRICAL DIARYL SULFONES; BOND FUNCTIONALIZATION; DIRECT ARYLATION; N-OXIDES; PALLADIUM; ARYL; ALKYLATION; C(SP(3))-H; ACIDS; C(SP(2))-H;
D O I：
10.1039/c5cc05527j
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Copper-catalysed direct C-H bond sulfonylation of aminoquinolines using commercially available and inexpensive arylsulfonyl chlorides as the sulfonylation reagents is described. The reactions took place exclusively at the C5-H position of the quinoline rings and tolerated a wide spectrum of functional groups. Moreover, synthetic transformations of the sulfonylated products led to useful compounds.
引用
收藏
页码：16928 / 16931
页数：4
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