Synthesis of 3,3′-carbonyl-bis(chromones) and their activity as mammalian alkaline phosphatase inhibitors

被引：30
|
作者：
Miliutina, Mariia [1 ]
Ejaz, Syeda Abida [2 ]
Iaroshenko, Viktor O. [1 ,3 ]
Villinger, Alexander [1 ]
Iqbal, Jamshed [2 ]
Langer, Peter [1 ,4 ]
机构：
[1] Univ Rostock, Inst Chem, D-18059 Rostock, Germany
[2] COMSATS Inst Informat Technol, Ctr Adv Drug Res, Abbottabad, Pakistan
[3] Natl Taras Shevchenko Univ, UA-01033 Kiev, Ukraine
[4] Univ Rostock EV, Leibniz Inst Katalyse, D-18059 Rostock, Germany
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 02期
关键词：
BONE MINERALIZATION; CHAMAEJASMINE; BIFLAVONOIDS; CALCIFICATION; APOPTOSIS; POTENT; CELLS;
D O I：
10.1039/c5ob01350j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Hitherto unknown 3,3'-carbonyl-bis(chromones) 8, dimeric chromones bridged by a carbonyl group, were prepared by reaction of chromone-3-carboxylic acid chloride with 3-(dimethylamino)-1-(2-hydroxyphenyl)-2-propen-1-ones 9. The method is generally applicable for the synthesis of novel symmetrical or non-symmetrical products which were found to inhibit mammalian alkaline phosphatases.
引用
收藏
页码：495 / 502
页数：8
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