Synthesis of 3,3′-carbonyl-bis(chromones) and their activity as mammalian alkaline phosphatase inhibitors

被引：31

作者：

Miliutina, Mariia ^{[1
]}

Ejaz, Syeda Abida ^{[2
]}

Iaroshenko, Viktor O. ^{[1
,3
]}

Villinger, Alexander ^{[1
]}

Iqbal, Jamshed ^{[2
]}

Langer, Peter ^{[1
,4
]}

机构：

[1] Univ Rostock, Inst Chem, D-18059 Rostock, Germany

[2] COMSATS Inst Informat Technol, Ctr Adv Drug Res, Abbottabad, Pakistan

[3] Natl Taras Shevchenko Univ, UA-01033 Kiev, Ukraine

[4] Univ Rostock EV, Leibniz Inst Katalyse, D-18059 Rostock, Germany

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 02期

关键词：

BONE MINERALIZATION; CHAMAEJASMINE; BIFLAVONOIDS; CALCIFICATION; APOPTOSIS; POTENT; CELLS;

D O I：

10.1039/c5ob01350j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Hitherto unknown 3,3'-carbonyl-bis(chromones) 8, dimeric chromones bridged by a carbonyl group, were prepared by reaction of chromone-3-carboxylic acid chloride with 3-(dimethylamino)-1-(2-hydroxyphenyl)-2-propen-1-ones 9. The method is generally applicable for the synthesis of novel symmetrical or non-symmetrical products which were found to inhibit mammalian alkaline phosphatases.

引用

收藏

页码：495 / 502

页数：8

相关论文

共 32 条

[1] Identification of novel chromone based sulfonamides as highly potent and selective inhibitors of alkaline phosphatases [J].

al-Rashida, Mariya ;

Raza, Rabia ;

Abbas, Ghulam ;

Shah, Muhammad Shakil ;

Kostakis, George E. ;

Lecka, Joanna ;

Sevigny, Jean ;

Muddassar, Muhammad ;

Papatriantafyllopoulou, Constantina ;

Iqbal, Jamshed .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 66 :438-449

[2] SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF DISODIUM CROMOGLYCATE AND SOME RELATED COMPOUNDS [J].

CAIRNS, H ;

COX, JSG ;

MINSHULL, R ;

FITZMAUR.C ;

LORD, GH ;

LEE, TB ;

KING, J ;

JOHNSON, PB ;

HUNTER, D .

JOURNAL OF MEDICINAL CHEMISTRY, 1972, 15 (06) :583-+

[3] Synthesis of phospholipase A2 inhibitory biflavonoids [J].

Chen, JJ ;

Chang, HW ;

Kim, HP ;

Park, H .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (09) :2373-2375

[4] KINETIC AND THERMODYNAMIC CONTROL IN THE LITHIATION OF 2,6-DIMETHYLCHROMONE, AND SELECTIVE LITHIATIONS IN 2-(X-FURYL)CHROMONES AND IN FURANOCHROMONES RELATED TO KHELLIN [J].

COSTA, AMBSRCS ;

DEAN, FM ;

JONES, MA ;

SMITH, DA .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1986, (09) :1707-1712

[5] SYNTHESIS AND REACTIONS OF 3,3'-BICHROMONES AND 2,3'-BICHROMONES [J].

EIDEN, F ;

PRIELIPP, L .

ARCHIV DER PHARMAZIE, 1977, 310 (02) :109-115

[6] CHROMONYL-(3)-METHANOL-DERIVATIVES AND BISCHROMONYL-(3)-METHANE-DERIVATIVES [J].

EIDEN, F ;

LUFT, W .

ARCHIV DER PHARMAZIE, 1974, 307 (01) :12-17

[7] 2,2-BI-4-PYRONES - STUDIES OF 4-PYRONES [J].

EIDEN, F ;

PRIELIPP, L .

ARCHIV DER PHARMAZIE, 1974, 307 (06) :461-465

[8] BENZOPYRONES .14. SYNTHESIS AND ANTI-ALLERGIC PROPERTIES OF SOME N-TETRAZOLYLCARBOXAMIDES AND RELATED COMPOUNDS [J].

ELLIS, GP ;

BECKET, GJP ;

SHAW, D ;

WILSON, HK ;

VARDEY, CJ ;

SKIDMORE, IF .

JOURNAL OF MEDICINAL CHEMISTRY, 1978, 21 (11) :1120-1126

[9] BENZOPYRANS .17. TRIETHYLAMINE-MEDIATED TRANSFORMATION OF 4-OXO-4H-1-BENZOPYRAN-3-CARBOXALDEHYDE [J].

GHOSH, CK ;

BANDYOPADHYAY, C ;

TEWARI, N .

JOURNAL OF ORGANIC CHEMISTRY, 1984, 49 (15) :2812-2815

[10]

Harnisch H, 1973, LIEBIGS ANN CHEM, V765, P8

← 1 2 3 4 →