Therapeutic Opportunities in Inflammatory Bowel Disease: Mechanistic Dissection of Host-Microbiome Relationships

被引：188

作者：

Plichta, Damian R. ^{[1
]}

Graham, Daniel B. ^{[1
,2
,3
,4
,5
]}

Subramanian, Sathish ^{[6
]}

Xavier, Ramnik J. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[2] Massachusetts Gen Hosp, Ctr Computat & Integrat Biol, Boston, MA 02114 USA

[3] Harvard Med Sch, Boston, MA 02115 USA

[4] Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA

[5] MIT, Ctr Microbiome Informat & Therapeut, 77 Massachusetts Ave, Cambridge, MA 02139 USA

[6] Massachusetts Gen Hosp, Dept Med, Div Gastroenterol, Boston, MA 02114 USA

来源：

CELL | 2019年 / 178卷 / 05期

关键词：

REGULATORY T-CELLS; PROTEIN-COUPLED RECEPTOR; GUT MICROBIOME; ULCERATIVE-COLITIS; ANTIGEN DISCOVERY; CROHNS-DISEASE; E; COLI; INDUCTION; ACID; COLONIZATION;

D O I：

10.1016/j.cell.2019.07.045

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The current understanding of inflammatory bowel disease (IBD) pathogenesis implicates a complex interaction between host genetics, host immunity, microbiome, and environmental exposures. Mechanisms gleaned from genetics and molecular pathogenesis offer clues to the critical triggers of mucosal inflammation and guide the development of therapeutic interventions. A complex network of interactions between host genetic factors, microbes, and microbial metabolites governs intestinal homeostasis, making classification and mechanistic dissection of involved pathways challenging. In this Review, we discuss these challenges, areas of active translation, and opportunities for development of next-generation therapies.

引用

页码：1041 / 1056

页数：16

共 50 条

[31] Irritable bowel syndrome, inflammatory bowel disease and the microbiome
Major, Giles
Spiller, Robin
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY, 2014, 21 (01) : 15 - 21
[32] A multi-omics spatial framework for host-microbiome dissection within the intestinal tissue microenvironment
Zhu, Bokai
Bai, Yunhao
Yeo, Yao Yu
Lu, Xiaowei
Rovira-Clave, Xavier
Chen, Han
Yeung, Jason
Nkosi, Dingani
Glickman, Jonathan
Delgado-Gonzalez, Antonio
Gerber, Georg K.
Angelo, Mike
Shalek, Alex K.
Nolan, Garry P.
Jiang, Sizun
NATURE COMMUNICATIONS, 2025, 16 (01)
[33] The gut microbiome: Relationships with disease and opportunities for therapy
Durack, Juliana
Lynch, Susan V.
JOURNAL OF EXPERIMENTAL MEDICINE, 2019, 216 (01): : 20 - 40
[34] Implications For Inflammation and Host-Microbiome Interactions In Bowel Dysfunction And Pain After Spinal Cord Injury
Willits, Adam
Kader, Leena
Eller, Olivia
Baumbauer, Kyle
JOURNAL OF PAIN, 2022, 23 (05): : 1 - 1
[35] Intestinal microbiome in short bowel syndrome: diagnostic and therapeutic opportunities
Chowdhury, Fariha
Hill, Lee
Shah, Nyah
Popov, Jelena
Cheveldayoff, Paige
Pai, Nikhil
CURRENT OPINION IN GASTROENTEROLOGY, 2023, 39 (06) : 463 - 471
[36] Pathological and therapeutic interactions between bacteriophages,microbes and the host in inflammatory bowel disease
Janka Babickova
Roman Gardlik
World Journal of Gastroenterology, 2015, (40) : 11321 - 11330
[37] Pathological and therapeutic interactions between bacteriophages, microbes and the host in inflammatory bowel disease
Babickova, Janka
Gardlik, Roman
WORLD JOURNAL OF GASTROENTEROLOGY, 2015, 21 (40) : 11321 - 11330
[38] Immune cell trafficking and retention in inflammatory bowel disease: mechanistic insights and therapeutic advances
Zundler, Sebastian
Becker, Emily
Schulze, Lisa Lou
Neurath, Markus F.
GUT, 2019, 68 (09) : 1688 - 1700
[39] Alteration of the Gut Microbiome in Inflammatory Bowel Disease
Andoh, Akira
Nishida, Atsushi
DIGESTION, 2023, 104 (01) : 16 - 23
[40] Inflammatory Bowel Disease as a Model for Translating the Microbiome
Huttenhower, Curtis
Kostic, Aleksandar D.
Xavier, Ramnik J.
IMMUNITY, 2014, 40 (06) : 843 - 854

← 1 2 3 4 5 →