Factors Associated With Infarct-Related Artery Patency Before Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction (from the FAST-MI 2010 Registry)

被引：15

作者：

Bailleul, Clotilde ^{[1
,3
]}

Puymirat, Etienne ^{[1
,3
]}

Aissaoui, Nadia ^{[2
]}

Schiele, Francois ^{[4
]}

Ducrocq, Gregory ^{[5
,6
,7
]}

Coste, Pierre ^{[8
]}

Blanchard, Didier ^{[9
]}

Brasselet, Camille ^{[10
]}

Elbaz, Meyer ^{[11
]}

Steg, Philippe Gabriel ^{[5
,6
,7
]}

Le Breton, Herve ^{[12
]}

Bonnefoy-Cudraz, Eric ^{[13
]}

Montalescot, Gilles ^{[14
]}

Cottin, Yves ^{[15
]}

Goldstein, Patrick ^{[16
]}

Ferrieres, Jean ^{[11
]}

Simon, Tabassome ^{[17
,18
]}

Danchin, Nicolas ^{[1
,3
]}

机构：

[1] Hop Europeen Georges Pompidou, AP HP, Dept Cardiol, Paris, France

[2] Hop Europeen Georges Pompidou, AP HP, Dept Intens Care Unit, Paris, France

[3] Univ Paris 05, Paris, France

[4] Univ Hosp Jean Minjoz, Dept Cardiol, Besancon, France

[5] Hop Bichat Claude Bernard, AP HP, Dept Cardiol, F-75877 Paris, France

[6] Univ Paris Diderot, Sorbonne Paris Cite, Paris, France

[7] INSERM, U698, Paris, France

[8] Hosp Haut Leveque, Dept Cardiol, Pessac, France

[9] Clin St Gatien, Dept Cardiol, Tours, France

[10] Clin Courlancy, Dept Cardiol, Reims, France

[11] Hop Rangueil, Dept Cardiol, Toulouse, France

[12] Univ Hosp Rennes, Dept Cardiol, Rennes, France

[13] Hop Cardiol Lyon, Dept Cardiol, Lyon, France

[14] Ctr Hosp Pitie Salpetriere, Dept Cardiol, Inst Cardiol, Paris, France

[15] Hosp Bocage, Univ Hosp Ctr, Dept Cardiol, Dijon, France

[16] Univ Hosp, Emergency Dept, Lille, France

[17] Hop St Antoine, AP HP, Unite Rech Clin, Dept Clin Pharmacol, F-75571 Paris, France

[18] Univ Paris 06, Paris, France

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2016年 / 117卷 / 01期

关键词：

PRETREATMENT; CLOPIDOGREL; INHIBITORS; MORTALITY;

D O I：

10.1016/j.amjcard.2015.09.043

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Early infarct-related artery (IRA) patency is associated with better clinical outcomes in patients with ST-elevation myocardial infarction (STEMI). Using the French Registry of ST-elevation and non ST-elevation Myocardial Infarction (FAST-MI) 2010 registry, we investigated factors related to IRA patency (thrombolysis in myocardial infarction [TIM1] 2/3 flow) at the start of procedure in patients admitted for primary percutaneous coronary intervention. FAST-MI 2010 is a nationwide French registry including 4,169 patients with acute MI. Of 1,452 patients with STEMI with primary percutaneous coronary intervention, 466 (32%) had TIMI 2/3 flow of IRA before the procedure. Mean age (62 14 years in both groups), Global Registry of Acute Coronary Event score (141 31 vs 142 34), and time from onset to angiography (472 499 vs 451 479 minutes) did not differ according to IRA patency (TEM 2/3 vs TIMI 0/1). Using multivariate logistic regression analysis, IRA patency was more frequently found in patients having called earlier (time from onset to electrocardiogram [ECG] < 120 minutes; odds ratio [OR] 1.49; 95% confidence interval [CI] 1.17 to 1.89), or receiving rapid-onset of action (prasugrel or glycoprotein IIb-IIIa) antiplatelet therapy in the prehospital setting (OR 1.59, 95% CI 1.14 to 2.21). Increasing time from diagnostic ECG to angiography was also associated with IRA patency (> 90 minutes; OR 1.37, 95% CI 1.08 to 1.75). In conclusion, preprocedural IRA patency is observed in one third of patients with STEML it is more frequently found in patients having received fastacting antiplatelet therapy before angiography, and in patients having called early. Higher IRA patency with increasing time delays from qualifying ECG to angiography suggests an additional role of spontaneous or medication-mediated fibrinolysis. (c) 2016 Elsevier Inc. All rights reserved.

引用

页码：17 / 21

页数：5

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