Improved left ventricular relaxation during short-term right ventricular outflow tract compared to apical pacing

Study objectives: Pacing-induced asynchrony may deteriorate left ventricular function; however, limited data exists in humans. The aim of our study was to compare left ventricular hemodynamics during short-term atrioventricular sequential pacing from the light ventricular apes and from the outflow tract of the right ventricle. Design: Three 5-min pacing intervals were applied in a random order, at a rate of 15 beats/min above the resting sinus rate. Atrioventricular sequential pacing from the two sites was compared with atrial pacing. During each pacing mode, left ventricular pressure was recorded, and cardiac output was calculated using Doppler echocardiography. Setting: Cardiac catheterization laboratory. Patients: Twenty patients (18 male, mean age 62 +/- 11 years) without structural heart disease were studied. Results: During atrial pacing, maximum negative first derivative of pressure (dp/dj) was 1,535 +/- 228 mm Hg/s; during pacing from the apes it decreased to 1,221 a 294 mm Hds (p = 0.0001), but was not significantly different during pacing from the outflow tract (1,431 +/- 435 mm Hg/s, p > 0.05). Isovolumic relaxation time constant (1) during atrial pacing was 39.7 +/- 11.9 ms; during pacing from the apes, it increased to 11.9 +/- 14.0 (p = 0.001), but was not significantly, different during pacing from the outflow tract (42.5 +/- 11.2, p > 0.05). Peak systolic pressure decreased significantly during atrioventricular sequential pacing from either site; however, it did not differ between the two sites. No differences in end-diastolic pressure, maximum positive dp/dt, or cardiac output could be demonstrated. Conclusion: In patients with no structural heart disease, short-term right ventricular outflow tract pacing is associated with more favorable diastolic function, compared to light ventricular epical pacing.