Hypoxia and tumor-associated macrophages A deadly alliance in support of tumor progression

被引：27

作者：

Van Overmeire, Eva

Laoui, Damya

Keirsse, Jiri

Van Ginderachter, Jo A. ^{[1
]}

机构：

[1] Vrije Univ Brussel, Cellular & Mol Immunol Lab, Brussels, Belgium

来源：

ONCOIMMUNOLOGY | 2014年 / 3卷 / 01期

关键词：

tumor-associated macrophage; M1; CD206; hypoxia; nanobody; PHD2; M2; molecular imaging;

D O I：

10.4161/onci.27561

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor-associated macrophages (TAMs) provide a significant contribution to tumor growth and metastasis. We demonstrated the existence of two main TAM subsets, differing in activation state and localization. Of these, M2-like TAMs reside in hypoxic regions of the tumor mass and can be used as targets for hypoxia tracers. This said, hypoxia does not regulate the differentiation of TAMs but finely tunes the activity of the M2-like population.

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