Overweight, obesity and cancer: Epidemiological evidence and proposed mechanisms

被引：2581
|
作者：
Calle, EE
Kaaks, R
机构：
[1] Int Agcy Res Canc, F-69372 Lyon 08, France
[2] Amer Canc Soc, Atlanta, GA 30306 USA
来源：
NATURE REVIEWS CANCER | 2004年 / 4卷 / 08期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrc1408
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The prevalence of obesity is rapidly increasing globally. Epidemiological studies have associated obesity with a range of cancer types, although the mechanisms by which obesity induces or promotes tumorigenesis vary by cancer site. These include insulin resistance and resultant chronic hyperinsulinaemia, increased bioavailability of steroid hormones and localized inflammation. Gaining a better understanding of the relationship between obesity and cancer can provide new insight into mechanisms of cancer pathogenesis.
引用
收藏
页码：579 / 591
页数：13
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