Introduction: A hypercoagulable state is a predisposition for venous thromboembolism (VTE). The activated partial thromboplastin time (aPTT)-based clot waveform analysis (CWA) is a global haemostatic measure but its role in assessment of hypercoagulability and thrombotic disorders is uncertain. We aimed to study the changes of CWA parameters in acute VTE. We hypothesized that patients with acute VTE would demonstrate higher CWA values than control patients without VTE and having elevated CWA parameters is associated with acute VTE. Materials and methods: Clot waveform analysis data from patients (N = 45) with objectively proven acute VTE who had an aPTT performed prior to initiation of anticoagulation were compared with controls (N = 111). The CWA parameters measured were min1, min2, max2 and delta change. Results: While the mean aPTT between VTE patients and controls did not differ (P = 0.830), the mean CWA parameters were significantly higher among VTE patients than controls (min1, P < 0.001; min2, P = 0.001; max2, P = 0.002; delta change, P < 0.001). There were significantly more cases within the VTE group exhibiting CWA values above their reference intervals than the control group (all P < 0.001), with the odds ratios for VTE of 8.0, 5.2, 4.8 and 18.6 for min1, min2, max2 and delta change, respectively (all P < 0.001). Conclusions: Patients with acute VTE had elevated aPTT-based CWA parameters than controls. Higher CWA parameters were significantly associated with acute VTE.
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Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, SingaporeNanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore
Ng, Chen Lin
Uy, Felix Maverick
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Natl Heart Ctr Singapore, Dept Cardiol, Singapore, SingaporeNanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore
Uy, Felix Maverick
Cheong, May Anne
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Singapore Gen Hosp, Dept Haematol, Singapore, SingaporeNanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore
Cheong, May Anne
Wong, Wan Hui
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Singapore Gen Hosp, Dept Haematol, Singapore, SingaporeNanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore
Wong, Wan Hui
Lau, Yee How
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Natl Heart Ctr Singapore, Dept Cardiol, Singapore, SingaporeNanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore
Lau, Yee How
Ng, Heng Joo
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Singapore Gen Hosp, Dept Haematol, Singapore, Singapore
Duke NUS Med Sch, Singapore, SingaporeNanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore
Ng, Heng Joo
Yeo, Khung Keong
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Natl Heart Ctr Singapore, Dept Cardiol, Singapore, Singapore
Duke NUS Med Sch, Singapore, SingaporeNanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore
Yeo, Khung Keong
Tan, Chuen Wen
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Singapore Gen Hosp, Dept Haematol, Singapore, Singapore
Duke NUS Med Sch, Singapore, SingaporeNanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore
机构:
Christian Med Coll & Hosp, Dept Transfus Med & Immunohematol, Vellore, Tamil Nadu, IndiaChristian Med Coll & Hosp, Dept Transfus Med & Immunohematol, Vellore, Tamil Nadu, India
Dave, Rutvi G.
Geevar, Tulasi
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Christian Med Coll & Hosp, Dept Transfus Med & Immunohematol, Vellore, Tamil Nadu, IndiaChristian Med Coll & Hosp, Dept Transfus Med & Immunohematol, Vellore, Tamil Nadu, India
Geevar, Tulasi
Mammen, Joy J.
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Christian Med Coll & Hosp, Dept Transfus Med & Immunohematol, Vellore, Tamil Nadu, IndiaChristian Med Coll & Hosp, Dept Transfus Med & Immunohematol, Vellore, Tamil Nadu, India
Mammen, Joy J.
Vijayan, Ramya
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Christian Med Coll & Hosp, Dept Transfus Med & Immunohematol, Vellore, Tamil Nadu, IndiaChristian Med Coll & Hosp, Dept Transfus Med & Immunohematol, Vellore, Tamil Nadu, India
Vijayan, Ramya
Mahasampath, Gowri
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Christian Med Coll & Hosp, Dept Biostat, Vellore, Tamil Nadu, IndiaChristian Med Coll & Hosp, Dept Transfus Med & Immunohematol, Vellore, Tamil Nadu, India
Mahasampath, Gowri
Nair, Sukesh C.
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Christian Med Coll & Hosp, Dept Transfus Med & Immunohematol, Vellore, Tamil Nadu, IndiaChristian Med Coll & Hosp, Dept Transfus Med & Immunohematol, Vellore, Tamil Nadu, India