Elevated activated partial thromboplastin time-based clot waveform analysis markers have strong positive association with acute venous thromboembolism

被引:16
|
作者
Tan, Chuen Wen [1 ]
Cheen, McVin Hua Heng [2 ]
Wong, Wan Hui [1 ]
Wu, Ian Qianhuang [1 ]
Chua, Brian Lee Wei [1 ]
Ahamedulla, Sahul Hameed [1 ]
Lee, Lai Heng [1 ]
Ng, Heng Loo [1 ]
机构
[1] Singapore Gen Hosp, Dept Hematol, Singapore, Singapore
[2] Singapore Gen Hosp, Dept Pharm, Singapore, Singapore
关键词
blood coagulation; activated partial thromboplastin time; thrombophilia; thrombosis; venous thromboembolism; INCREASED RISK; THROMBIN GENERATION; D-DIMER; HEMOPHILIA-A; DIAGNOSIS; COAGULATION; PLASMA;
D O I
10.11613/BM.2019.020710
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Introduction: A hypercoagulable state is a predisposition for venous thromboembolism (VTE). The activated partial thromboplastin time (aPTT)-based clot waveform analysis (CWA) is a global haemostatic measure but its role in assessment of hypercoagulability and thrombotic disorders is uncertain. We aimed to study the changes of CWA parameters in acute VTE. We hypothesized that patients with acute VTE would demonstrate higher CWA values than control patients without VTE and having elevated CWA parameters is associated with acute VTE. Materials and methods: Clot waveform analysis data from patients (N = 45) with objectively proven acute VTE who had an aPTT performed prior to initiation of anticoagulation were compared with controls (N = 111). The CWA parameters measured were min1, min2, max2 and delta change. Results: While the mean aPTT between VTE patients and controls did not differ (P = 0.830), the mean CWA parameters were significantly higher among VTE patients than controls (min1, P < 0.001; min2, P = 0.001; max2, P = 0.002; delta change, P < 0.001). There were significantly more cases within the VTE group exhibiting CWA values above their reference intervals than the control group (all P < 0.001), with the odds ratios for VTE of 8.0, 5.2, 4.8 and 18.6 for min1, min2, max2 and delta change, respectively (all P < 0.001). Conclusions: Patients with acute VTE had elevated aPTT-based CWA parameters than controls. Higher CWA parameters were significantly associated with acute VTE.
引用
收藏
页码:385 / 393
页数:9
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