CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells

被引：16

作者：

Lian, Haiwei ^{[1
,2
,3
]}

Li, Dun ^{[2
,4
]}

Zhou, Yun ^{[2
,5
]}

Landesman-Bollag, Esther ^{[4
]}

Zhang, Guanglan ^{[6
]}

Anderson, Nicole M. ^{[2
]}

Tang, Kevin Charles ^{[2
]}

Roderick, Justine E. ^{[7
]}

Kelliher, Michelle A. ^{[7
]}

Seldin, David C. ^{[4
]}

Fu, Hui ^{[1
]}

Feng, Hui ^{[2
,4
]}

机构：

[1] Wuhan Univ, Sch Basic Med Sci, Dept Anat & Embryol, Wuhan, Hubei, Peoples R China

[2] Boston Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Boston, MA 02215 USA

[3] Wuhan Univ, Renmin Hosp, Dept Neurosurg, Wuhan, Hubei, Peoples R China

[4] Boston Univ, Sch Med, Dept Med, Sect Hematol & Med Oncol, Boston, MA 02215 USA

[5] Wuhan Univ, Renmin Hosp, Dept Gynaecol, Wuhan, Hubei, Peoples R China

[6] Boston Univ, Metropolitan Coll, Dept Comp Sci, Boston, MA 02215 USA

[7] Univ Massachusetts, Sch Med, Dept Mol Cell & Canc Biol, Worcester, MA USA

来源：

关键词：

PATHWAY; MYC; RESISTANCE; THERAPY; GROWTH;

D O I：

10.3324/haematol.2016.154013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：E17 / E21

页数：5

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