Secretory leucoprotease inhibitor impairs toll-like receptor 2-and 4-mediated responses in monocytic cells

被引：70

作者：

Greene, CM ^{[1
]}

McElvaney, NG ^{[1
]}

O'Neill, SJ ^{[1
]}

Taggart, CC ^{[1
]}

机构：

[1] Beaumont Hosp, Royal Coll Surg Ireland, Resp Res Div, Educ & Res Ctr, Dublin 9, Ireland

来源：

INFECTION AND IMMUNITY | 2004年 / 72卷 / 06期

关键词：

D O I：

10.1128/IAI.72.6.3684-3687.2004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Secretory leucoprotease inhibitor (SLPI) is an anti-inflammatory antiprotease which can inhibit lipopolysaccharide-induced NF-kappaB activation. We examined its ability to inhibit NF-kappaB activation induced by lipoteichoic acid and investigated the effects of oxidation or complex formation with neutrophil elastase on SLPI's anti-inflammatory properties in U937 myelomonocytic cells and macrophages.

引用

页码：3684 / 3687

页数：4

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