Regulation of stem cell fate by HSPGs: implication in hair follicle cycling

被引：15

作者：

Colin-Pierre, Charlie ^{[1
,2
,3
]}

El Baraka, Oussama ^{[3
]}

Danoux, Louis ^{[3
]}

Bardey, Vincent ^{[3
]}

Andre, Valerie ^{[3
]}

Ramont, Laurent ^{[1
,2
,4
]}

Brezillon, Stephane ^{[1
,2
]}

机构：

[1] Univ Reims, Lab Biochim Med & Biol Mol, SFR CAP Sante FED 4231, Reims, France

[2] CNRS UMR 7369, Matrice Extracellulaire & Dynam Cellulaire MEDyC, Reims, France

[3] BASF Beauty Care Solut France SAS, Pulnoy, France

[4] CHU Reims, Serv Biochim Pharmacol Toxicol, Reims, France

来源：

NPJ REGENERATIVE MEDICINE | 2022年 / 7卷 / 01期

关键词：

HEPARAN-SULFATE PROTEOGLYCANS; EPITHELIAL-MESENCHYMAL INTERACTIONS; HEMATOPOIETIC PROGENITOR CELLS; FIBROBLAST-GROWTH; SONIC HEDGEHOG; DERMAL PAPILLA; CHONDROCYTE PROLIFERATION; SERGLYCIN PROTEOGLYCAN; SYNDECAN-3; EXPRESSION; GRADIENT FORMATION;

D O I：

10.1038/s41536-022-00267-y

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Heparan sulfate proteoglycans (HSPGs) are part of proteoglycan family. They are composed of heparan sulfate (HS)-type glycosaminoglycan (GAG) chains covalently linked to a core protein. By interacting with growth factors and/or receptors, they regulate numerous pathways including Wnt, hedgehog (Hh), bone morphogenic protein (BMP) and fibroblast growth factor (FGF) pathways. They act as inhibitor or activator of these pathways to modulate embryonic and adult stem cell fate during organ morphogenesis, regeneration and homeostasis. This review summarizes the knowledge on HSPG structure and classification and explores several signaling pathways regulated by HSPGs in stem cell fate. A specific focus on hair follicle stem cell fate and the possibility to target HSPGs in order to tackle hair loss are discussed in more dermatological and cosmeceutical perspectives.

引用

页数：17

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