Altered erythrocyte sodium-lithium counter-transport and Na+/K+-ATPase activity in cystic fibrosis

被引:5
作者
Luczay, A
Vasarhelyi, B
Dobos, M
Holics, K
Ujhelyi, R
Tulassay, T
机构
[1] SEMMELWEIS UNIV MED,DEPT PAEDIAT 1,H-1083 BUDAPEST,HUNGARY
[2] POSTGRAD MED UNIV,DEPT PAEDIAT 1,BUDAPEST,HUNGARY
关键词
cystic fibrosis; Na+/K+-ATPase sodium homeostasis; Na+-Li+ counter-transport;
D O I
10.1111/j.1651-2227.1997.tb08883.x
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Patients with cystic fibrosis (CF) exhibit normal concentrations of sodium and chloride in spite of the disturbance of Cl- and Na+ transport in epithelial cells. To characterize compensatory mechanisms in the regulation of sodium homeostasis, erythrocytes of 13 CF patients were analysed for sodium-lithium counter-transport (SLC), Na+/K+-ATPase activity and intracellular sodium content. Values were compared to those of healthy controls. Patients with CF had normal serum sodium and chloride concentrations and renal excretions of these ions were within the physiological range. Intracellular sodium concentration was similar in the CF and the control group (6.8 +/- 2.2 vs 5.7 +/- 1.0 mmol/l RBCs). Red blood cells' SLC and Na+/K+-ATPase activity were elevated in CF patients (381 +/- 106 mu mol/h/l RBCs vs 281 +/- 64; p < 0.01) and (445 +/- 129 mu mol ATP mg prot/h vs 322 +/- 84, p < 0.01). Our study demonstrates that transmembrane cation transport systems are highly activated in CF. The increased sodium transport may be part of a compensatory mechanism of sodium homeostasis in children with CF.
引用
收藏
页码:245 / 247
页数:3
相关论文
共 12 条
[1]   RENAL-FUNCTION IN CYSTIC-FIBROSIS WITH SPECIAL REFERENCE TO THE RENAL SODIUM HANDLING [J].
BERG, U ;
KUSOFFSKY, E ;
STRANDVIK, B .
ACTA PAEDIATRICA SCANDINAVICA, 1982, 71 (05) :833-838
[2]  
BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[3]   INCREASED SODIUM-LITHIUM COUNTERTRANSPORT IN RED-CELLS OF PATIENTS WITH ESSENTIAL-HYPERTENSION [J].
CANESSA, M ;
ADRAGNA, N ;
SOLOMON, HS ;
CONNOLLY, TM ;
TOSTESON, DC .
NEW ENGLAND JOURNAL OF MEDICINE, 1980, 302 (14) :772-776
[4]   RED-CELL SODIUM-LITHIUM COUNTERTRANSPORT AND BLOOD-PRESSURE IN CHILDREN WITH INSULIN-DEPENDENT DIABETES-MELLITUS [J].
DOBOS, M ;
MADACSY, L ;
YASAR, SA ;
BRECKNER, M ;
KORNER, A ;
SZUCS, L ;
NAGY, I ;
TULASSAY, T .
DIABETES RESEARCH AND CLINICAL PRACTICE, 1994, 26 (01) :15-20
[5]   IS INCREASED ERYTHROCYTE SODIUM-LITHIUM COUNTERTRANSPORT A USEFUL MARKER FOR DIABETIC NEPHROPATHY [J].
ELVING, LD ;
WETZELS, JFM ;
DEPONT, JJHHM ;
BERDEN, JHM .
KIDNEY INTERNATIONAL, 1992, 41 (04) :862-871
[6]  
MAHNENSMITH RL, 1982, CIRC RES, V57, P773
[7]  
QUINTON PM, 1989, CLIN CHEM, V35, P726
[8]   ERYTHROCYTE SODIUM-POTASSIUM TRANSPORT IN CYSTIC-FIBROSIS [J].
SIGSTROM, L ;
STRANDVIK, B .
PEDIATRIC RESEARCH, 1992, 31 (05) :425-427
[9]   DECREASED RENAL CLEARANCE OF SODIUM IN CYSTIC-FIBROSIS [J].
STENVINKEL, P ;
HJELTE, L ;
ALVAN, G ;
HEDMAN, A ;
HULTMAN, E ;
STRANDVIK, B .
ACTA PAEDIATRICA SCANDINAVICA, 1991, 80 (02) :194-198
[10]  
STRANDVIK B, 1981, MONOGR PAEDIATR, V14, P36