Too Little mTORC1 Activity Injures the Liver

被引：3

作者：

Abraham, Robert T. ^{[1
]}

机构：

[1] Pfizer Worldwide Res & Dev, Oncol Res Unit, San Diego, CA 92121 USA

来源：

CELL METABOLISM | 2014年 / 20卷 / 01期

关键词：

HEPATOCELLULAR-CARCINOMA; AUTOPHAGY;

D O I：

10.1016/j.cmet.2014.06.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Obesity promotes chronic activation of mTORC1 and is a known risk factor for hepatic injury, inflammation, and carcinogenesis. In this issue, Umemura et al. (2014) demonstrate that a persistent reduction in hepatic mTORC1 activity also promotes cell damage and inflammation and sensitizes the liver to cancer development.

引用

页码：4 / 6

页数：4

共 9 条

[1] The mTOR pathway in hepatic malignancies
Bhat, Mamatha
Sonenberg, Nahum
Gores, Gregory J.
[J]. HEPATOLOGY, 2013, 58 (02) : 810 - 818
[2] Obesity and hepatocellular carcinoma
Caldwell, SH
Crespo, DM
Kang, HS
Al-Osaimi, AMS
[J]. GASTROENTEROLOGY, 2004, 127 (05) : S97 - S103
[3] The role of autophagy in liver cancer: Molecular mechanisms and potential therapeutic targets
Cui, Jianzhou
Gong, Zhiyuan
Shen, Han-Ming
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2013, 1836 (01): : 15 - 26
[4] Chronic Activation of mTOR Complex 1 Is Sufficient to Cause Hepatocellular Carcinoma in Mice
Menon, Suchithra
Yecies, Jessica L.
Zhang, Hui H.
Howell, Jessica J.
Nicholatos, Justin
Harputlugil, Eylul
Bronson, Roderick T.
Kwiatkowski, David J.
Manning, Brendan D.
[J]. SCIENCE SIGNALING, 2012, 5 (217)
[5] Liver Stem Cells and Hepatocellular Carcinoma
Mishra, Lopa
Banker, Tanuj
Murray, Joseph
Byers, Stephen
Thenappan, Arun
He, Aiwu Ruth
Shetty, Kirti
Johnson, Lynt
Reddy, E. P.
[J]. HEPATOLOGY, 2009, 49 (01) : 318 - 329
[6] Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes
Narita, Masako
Young, Andrew R. J.
Arakawa, Satoko
Samarajiwa, Shamith A.
Nakashima, Takayuki
Yoshida, Sei
Hong, Sungki
Berry, Lorraine S.
Reichelt, Stefanie
Ferreira, Manuela
Tavare, Simon
Inoki, Ken
Shimizu, Shigeomi
Narita, Masashi
[J]. SCIENCE, 2011, 332 (6032) : 966 - 970
[7] The Etiology of Hepatocellular Carcinoma and Consequences for Treatment
Sanyal, Arun J.
Yoon, Seung Kew
Lencioni, Riccardo
[J]. ONCOLOGIST, 2010, 15 : 14 - 22
[8] Liver Damage, Inflammation, and Enhanced Tumorigenesis after Persistent mTORC1 Inhibition
Umemura, Atsushi
Park, Eek Joong
Taniguchi, Koji
Lee, Jun Hee
Shalapour, Shabnam
Valasek, Mark A.
Aghajan, Mariam
Nakagawa, Hayato
Seki, Ekihiro
Hall, Michael N.
Karin, Michael
[J]. CELL METABOLISM, 2014, 20 (01) : 133 - 144
[9] Therapeutic potential and adverse events of everolimus for treatment of hepatocellular carcinoma - systematic review and meta-analysis
Yamanaka, Kenya
Petrulionis, Marius
Lin, Shibo
Gao, Chao
Galli, Uwe
Richter, Susanne
Winkler, Susanne
Houben, Philipp
Schultze, Daniel
Hatano, Etsuro
Schemmer, Peter
[J]. CANCER MEDICINE, 2013, 2 (06): : 862 - 871

← 1 →