PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition

被引：387

作者：

Lancaster, Alex K. ^{[1
,2
,3
]}

Nutter-Upham, Andrew ^{[1
]}

Lindquist, Susan ^{[1
,4
,5
]}

King, Oliver D. ^{[6
]}

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA USA

[3] Harvard Univ, Sch Med, Ctr Biomed Informat, Boston, MA 02115 USA

[4] MIT, Dept Biol, Cambridge, MA 02139 USA

[5] MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA

[6] Univ Massachusetts, Sch Med, Dept Cell & Dev Biol, Worcester, MA 01655 USA

来源：

BIOINFORMATICS | 2014年 / 30卷 / 17期

基金：

美国国家卫生研究院;

关键词：

DOMAINS; SEQUENCE;

D O I：

10.1093/bioinformatics/btu310

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A Summary: Prions are self-templating protein aggregates that stably perpetuate distinct biological states and are of keen interest to researchers in both evolutionary and biomedical science. The best understood prions are from yeast and have a prion-forming domain with strongly biased amino acid composition, most notably enriched for Q or N. PLAAC is a web application that scans protein sequences for domains with prion-like amino acid composition. Users can upload sequence files, or paste sequences directly into a textbox. PLAAC ranks the input sequences by several summary scores and allows scores along sequences to be visualized. Text output files can be downloaded for further analyses, and visualizations saved in PDF and PNG formats.

引用

页码：2501 / 2502

页数：2

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