Annual Research Review: The neuroinflammation hypothesis for stress and psychopathology in children - developmental psychoneuroimmunology

被引：39
作者：
O'Connor, Thomas G. [1 ]
Moynihan, Jan A. [1 ]
Caserta, Mary T. [1 ]
机构：
[1] Univ Rochester, Med Ctr, Rochester, NY 14642 USA
来源：
JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY | 2014年 / 55卷 / 06期
基金：
美国国家卫生研究院;
关键词：
Immunology; psychoneuroimmunology; neuroinflammation; stress; developmental psychopathology; ADVERSE CHILDHOOD EXPERIENCES; C-REACTIVE PROTEIN; SOCIOECONOMIC-STATUS; PRENATAL STRESS; IMMUNE FUNCTION; PSYCHOLOGICAL STRESS; PSYCHOSOCIAL STRESS; CYTOKINE PRODUCTION; ADAPTIVE IMMUNITY; CUMULATIVE RISK;
D O I：
10.1111/jcpp.12187
中图分类号：
B844 [发展心理学（人类心理学）];
学科分类号：
040202 ;
摘要：
Experimental animal and adult human data suggest that stress exposure is associated with alterations in immune system function that may underlie increased susceptibility to disease and behavioral disorders. The implications of these data for child psychology and psychiatry are not yet clear. The current review seeks to distil and translate the relevant animal and adult human work to children to advance a developmental model of psychoneuroimmunology. In addition to reviewing key specific findings, we consider biological/conceptual models and technical aspects of psychoneuroimmunology work in pediatric populations, and outline the rationales and advantages of integrating hypotheses concerning neuroinflammation in developmental studies of psychopathology.
引用
收藏
页码：615 / 631
页数：17
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