Physicochemical investigations on non-covalent interactions between Padimate O and cyclodextrin receptors in both solution and solid states

Ultraviolet B (UV-B) radiation is very harmful to human body. It can cause serious health problem mainly skin cancer, sunburn and photo-aging. Padimate O (PMO) is a sunscreen agent. The aim of this work is to form inclusion complexes with alpha-cyd and beta-cyd in both aqueous environment and solid state that established by UV-Vis, FTIR spectroscopy, mass spectra, powder X-ray diffraction pattern and as alpha-cyd and beta-cyd are known to us as good drug vehicles, hence, the experimental results suggest that they can be used as good sunscreen agent carrier and photostabilizer additive for increasing the photostability and other properties of PMO. In solution phase, UV-Vis spectroscopy demonstrated that the entire process of formation of complexes is observed with 1: 1 stoichiometry which is further justified by mass spectra. Thermodynamic parameters support the whole process in both cases and it is revealed that beta-cyd forms more firmly inclusion complex than alpha-cyd with PMO. Successful formation of solid inclusion complexes is supported by FTIR spectroscopy and powder-XRD. The enhancement of the thermal stability of the alpha-cyd/PMO and beta-cyd/PMO complexes is demonstrated by TGA study. Published by Elsevier B.V.