Brain structural correlates of alexithymia in patients with major depressive disorder

被引:17
作者
Foerster, Katharina [1 ]
Enneking, Verena [1 ]
Dohm, Katharina [1 ]
Redlich, Ronny [1 ]
Meinert, Susanne [1 ]
Geisler, Adina Isabel [1 ]
Leehr, Elisabeth Johanna [1 ]
Kugel, Harald [2 ]
Baune, Bernhard T. [1 ,3 ,5 ]
Arolt, Volker [1 ]
Zwitserlood, Pienie [4 ]
Grotegerd, Dominik [1 ]
Dannlowski, Udo [1 ]
机构
[1] Univ Munster, Dept Psychiat, Albert Schweitzer Campus 1,G A9, D-48149 Munster, Germany
[2] Univ Munster, Inst Clin Radiol, Munster, Germany
[3] Univ Melbourne, Dept Psychiat, Parkville, Vic, Australia
[4] Univ Munster, Dept Psychol, Munster, Germany
[5] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia
来源
JOURNAL OF PSYCHIATRY & NEUROSCIENCE | 2020年 / 45卷 / 02期
关键词
SOCIAL COGNITION; EMOTION; ASSOCIATION; HIPPOCAMPUS; PERCEPTION; SOMATOFORM; SEVERITY; DISTINCT; ILLNESS; BURDEN;
D O I
10.1503/jpn.190044
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Background Alexithymia is a risk factor for major depressive disorder (MDD) and has been associated with diminished treatment response. Neuroimaging studies have revealed structural aberrations of the anterior cingulate cortex and the fusiform gyrus in healthy controls with high levels of alexithymia. The present study tried to corroborate and extend these results to patients with MDD compared with healthy controls. Methods We investigated the relationship between alexithymia, depression and grey matter volume in 63 patients with MDD (mean age +/- standard deviation = 42.43 yr +/- 11.91; 33 female) and 46 healthy controls (45.35 yr +/- 8.37; 22 female). We assessed alexithymia using the Toronto Alexithymia Scale. We conducted an alexithymia x group analysis of covariance; we used a region-of-interest approach, including the fusiform gyrus and anterior cingulate cortex, and conducted whole brain analysis using voxel-based morphometry. Results Our analysis revealed a significant alexithymia x group interaction in the fusiform gyrus (left, p(FWE) = 0.031; right, p(FWE) = 0.010). Higher alexithymia scores were associated with decreased grey matter volume in patients with MDD (p(FWE) = 0.009), but with increased grey matter volume of the fusiform gyrus in healthy controls (p(FWE) = 0.044). We found no significant main effects in the region-of-interest analysis. Limitations Owing to the naturalistic nature of our study, patients with MDD and healthy controls differed significantly in their alexithymia scores. Conclusion Our results showed the fusiform gyrus as a correlate of alexithymia. We also found differences related to alexithymia between patients with MDD and healthy controls in the fusiform gyrus. Our study encourages research related to the transition from risk to MDD in people with alexithymia.
引用
收藏
页码:117 / 124
页数:8
相关论文
共 57 条
[1]   Differential Effects of Early Life Stress on Hippocampus and Amygdala Volume as a Function of Emotional Abilities [J].
Aust, Sabine ;
Stasch, Joanna ;
Jentschke, Sebastian ;
Haertwig, Elif Alkan ;
Koelsch, Stefan ;
Heuser, Isabella ;
Bajbouj, Malek .
HIPPOCAMPUS, 2014, 24 (09) :1094-1101
[2]   THE 20-ITEM TORONTO-ALEXITHYMIA-SCALE .1. ITEM SELECTION AND CROSS-VALIDATION OF THE FACTOR STRUCTURE [J].
BAGBY, RM ;
PARKER, JDA ;
TAYLOR, GJ .
JOURNAL OF PSYCHOSOMATIC RESEARCH, 1994, 38 (01) :23-32
[3]   Alexithymia in DSM-IV disorder -: Comparative evaluation of somatoform disorder, panic disorder, obsessive-compulsive disorder, and depression [J].
Bankier, B ;
Aigner, M ;
Bach, M .
PSYCHOSOMATICS, 2001, 42 (03) :235-240
[4]  
Beck A.T., 1996, Beck Depression Inventory (BDI-II)
[5]   Processing of facial emotion expression in major depression: a review [J].
Bourke, Cecilia ;
Douglas, Katie ;
Porter, Richard .
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, 2010, 44 (08) :681-696
[6]   Systematic review of the neural basis of social cognition in patients with mood disorders [J].
Cusi, Andree M. ;
Nazarov, Anthony ;
Holshausen, Katherine ;
MacQueen, Glenda M. ;
McKinnon, Margaret C. .
JOURNAL OF PSYCHIATRY & NEUROSCIENCE, 2012, 37 (03) :154-169
[7]   Brain correlates of alexithymia in eating disorders: A voxel-based morphometry study [J].
D'Agata, Federico ;
Caroppo, Paola ;
Amianto, Federico ;
Spalatro, Angela ;
Caglio, Marcella M. ;
Bergui, Mauro ;
Lavagnino, Luca ;
Righi, Dorico ;
Abbate-Daga, Giovanni ;
Pinessi, Lorenzo ;
Mortara, Paolo ;
Fassino, Secondo .
PSYCHIATRY AND CLINICAL NEUROSCIENCES, 2015, 69 (11) :708-716
[8]   Neural mechanism of unconscious perception of surprised facial expression [J].
Duan, Xujun ;
Dai, Qian ;
Gong, Qiyong ;
Chen, Huafu .
NEUROIMAGE, 2010, 52 (01) :401-407
[9]   Alexithymia in somatoform and depressive disorders [J].
Duddu, V ;
Isaac, MK ;
Chaturvedi, SK .
JOURNAL OF PSYCHOSOMATIC RESEARCH, 2003, 54 (05) :435-438
[10]   DIFFICULTY IDENTIFYING FEELINGS AND AUTOMATIC ACTIVATION IN THE FUSIFORM GYRUS IN RESPONSE TO FACIAL EMOTION [J].
Eichmann, Mischa ;
Kugel, Harald ;
Suslow, Thomas .
PERCEPTUAL AND MOTOR SKILLS, 2008, 107 (03) :915-922