The clinical applications of a systems approach

被引:117
作者
Ahn, Andrew C. [1 ]
Tewari, Muneesh
Poon, Chi-Sang
Phillips, Russell S.
机构
[1] Harvard Univ, Sch Med, Div Res & Educ Complentary & Integrat Med Therapi, Boston, MA 02115 USA
[2] Beth Israel Deaconess Med Ctr, Div Gen Med & Primary Care, Boston, MA 02215 USA
[3] MIT, Adv Study Program, Cambridge, MA 02139 USA
[4] Fred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98104 USA
[5] Harvard Univ, MIT, Div Hlth Sci & Technol, Cambridge, MA 02139 USA
[6] MIT, Computat & Syst Biol Initiat, Cambridge, MA 02139 USA
关键词
D O I
10.1371/journal.pmed.0030209
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
[No abstract available]
引用
收藏
页码:956 / 960
页数:5
相关论文
共 44 条
[1]   The limits of reductionism in medicine: Could systems biology offer an alternative? [J].
Ahn, Andrew C. ;
Tewari, Muneesh ;
Poon, Chi-Sang ;
Phillips, Russell S. .
PLOS MEDICINE, 2006, 3 (06) :709-713
[2]   Evaluation of immunohistochemical markers in non-small cell lung cancer by unsupervised hierarchical clustering analysis: a tissue microarray study of 284 cases and 18 markers [J].
Au, NHC ;
Cheang, M ;
Huntsman, DG ;
Yorida, E ;
Coldman, A ;
Elliott, WM ;
Bebb, G ;
Flint, J ;
English, J ;
Gilks, CB ;
Grimes, HL .
JOURNAL OF PATHOLOGY, 2004, 204 (01) :101-109
[3]   SALICYLATES AS HYPOGLYCEMIC AGENTS [J].
BARON, SH .
DIABETES CARE, 1982, 5 (01) :64-71
[4]   ABSORPTION KINETICS AND BIOLOGIC EFFECTS OF SUBCUTANEOUSLY INJECTED INSULIN PREPARATIONS [J].
BERGER, M ;
CUPPERS, HJ ;
HEGNER, H ;
JORGENS, V ;
BERCHTOLD, P .
DIABETES CARE, 1982, 5 (02) :77-91
[5]  
Canaple L, 2003, CANCER RES, V63, P7545
[6]   Type 2 diabetes mellitus: a disease of the innate immune system? An update [J].
Crook, M .
DIABETIC MEDICINE, 2004, 21 (03) :203-207
[7]   Epilepsies as dynamical diseases of brain systems: Basic models of the transition between normal and epileptic activity [J].
da Silva, FL ;
Blanes, W ;
Kalitzin, SN ;
Parra, J ;
Suffczynski, P ;
Velis, DN .
EPILEPSIA, 2003, 44 :72-83
[8]   Inflammation: the link between insulin resistance, obesity and diabetes [J].
Dandona, P ;
Aljada, A ;
Bandyopadhyay, A .
TRENDS IN IMMUNOLOGY, 2004, 25 (01) :4-7
[9]   Archimedes - A trial-validated model of diabetes [J].
Eddy, DM ;
Schlessinger, L .
DIABETES CARE, 2003, 26 (11) :3093-3101
[10]   Obesity, inflammation and type II diabetes [J].
Finegood, DT .
INTERNATIONAL JOURNAL OF OBESITY, 2003, 27 (Suppl 3) :S4-S5