Short-Term Insulin Requirements Following Gastric Bypass Surgery in Severely Obese Women with Type 1 Diabetes

被引：16
作者：
Middelbeek, Roeland J. W. [1 ,4 ]
James-Todd, Tamarra [2 ,4 ]
Patti, Mary-Elizabeth [1 ,3 ,4 ]
Brown, Florence M. [1 ,3 ,4 ]
机构：
[1] Beth Israel Deaconess Med Ctr, Div Endocrinol Diabet & Metab, Boston, MA 02215 USA
[2] Brigham & Womens Hosp, Div Womens Hlth, Boston, MA 02120 USA
[3] Joslin Diabet Ctr, Boston, MA 02215 USA
[4] Harvard Univ, Sch Med, Boston, MA USA
来源：
OBESITY SURGERY | 2014年 / 24卷 / 09期
关键词：
Gastric bypass surgery; Type; 1; diabetes; Insulin requirements; BARIATRIC SURGERY; MEDICAL THERAPY; WEIGHT;
D O I：
10.1007/s11695-014-1228-8
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
In severely obese type 2 diabetes patients, gastric bypass surgery (GB) reduces body mass index (BMI) and hemoglobin A1c (HbA1c) and allows reduced doses of insulin and other medications. Data regarding the effects of GB on severely obese patients with type 1 diabetes are limited. Severely obese women with type 1 diabetes (n = 9) were studied immediately before and after GB (7.7 +/- 5.8 weeks, mean +/- SD). On average, GB reduced mean BMI by 11 % and mean HbA1c by 0.9 % (from 8.0 to 7.1 %), with a parallel 38 % decrease in basal insulin requirements (expressed per kilogram of body weight). GB rapidly decreased BMI, HbA1c, and insulin requirements in severely obese women with type 1 diabetes. However, physiologic insulin replacement remains necessary in patients with type 1 diabetes.
引用
收藏
页码：1442 / 1446
页数：5
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