An evolutionarily conserved mediator of plant disease resistance gene function is required for normal Arabidopsis development

被引：113
作者：
Holt, BF
Boyes, DC
Ellerström, M
Siefers, N
Wiig, A
Kauffman, S
Grant, MR
Dangl, JL
机构：
[1] Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA
[2] Univ London Imperial Coll Sci Technol & Med, Dept Biol Sci, Ashford TN25 5AH, Kent, England
[3] Univ N Carolina, Dept Microbiol & Immunol, Chapel Hill, NC 27599 USA
[4] Univ N Carolina, Curriculum Genet, Chapel Hill, NC 27599 USA
来源：
DEVELOPMENTAL CELL | 2002年 / 2卷 / 06期
关键词：
D O I：
10.1016/S1534-5807(02)00174-0
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Plants recognize many pathogens through the action of a diverse family of proteins called disease resistance (R) genes. The Arabidopsis R gene RPM1 encodes resistance to specific Pseudomonas syringae strains. We describe an RPM1-interacting protein that is an ortholog of TIP49a, previously shown to interact with the TATA binding protein (TBP) complex and to modulate c-myc- and beta-catenin-mediated signaling in animals. Reduction of Arabidopsis TIP49a (AtTIP49a) mRNA levels results in measurable increases of two R-dependent responses without constitutively activating defense responses, suggesting that AtTIP49a can act as a negative regulator of at least some R functions. Further, AtTIP49a is essential for both sporophyte and female gametophyte viability. Thus, regulators of R function overlap with essential modulators of plant development.
引用
收藏
页码：807 / 817
页数：11
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