Renal safety of tenofovir in HIV treatment-experienced patients

被引：146

作者：

Izzedine, H ^{[1
]}

Isnard-Bagnis, C

Hulot, JS

Vittecoq, D

Cheng, A

Jais, CK

Launay-Vacher, V

Deray, G

机构：

[1] Hop La Pitie Salpetriere, Dept Nephrol, Paris, France

[2] Hop La Pitie Salpetriere, Dept Clin Pharmacol, Paris, France

[3] Kremlin Bicetre Hosp, Dept Infect Dis, Paris, France

[4] Gilead Sci Inc, Foster City, CA 94404 USA

[5] AFSSAPS, French Hlth Prod Safety Agcy, St Denis, France

来源：

AIDS | 2004年 / 18卷 / 07期

关键词：

D O I：

10.1097/00002030-200404300-00019

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The safety of tenofovir disoproxil fumarate (TDF) was assessed in two double-blind, placebo-controlled studies. Furthermore, we retrospectively collected 19 cases of TDF-associated tubular dysfunction. The incidence of renal events was similar among the active TDF groups and the placebo group in the two double-blind, placebo-controlled studies. Proximal tubulopathy was diagnosed 6.89 +/- 5.51 months after TDF therapy started. All abnormalities normalized within 4.7 +/- 2.94 weeks after drug discontinuation.

引用

页码：1074 / 1076

页数：3

共 11 条

[1]

BLICK G, 2003, 10 C RETR OPP INF BO

[2] PATTERN OF GLOMERULAR INVOLVEMENT IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTED PATIENTS - AN ITALIAN STUDY [J].

CASANOVA, S ;

MAZZUCCO, G ;

DIBELGIOJOSO, GB ;

MOTTA, M ;

BOLDORINI, R ;

GENDERINI, A ;

MONGA, G .

AMERICAN JOURNAL OF KIDNEY DISEASES, 1995, 26 (03) :446-453

[3] Rapid communication: Acute renal failure associated with tenofovir: Evidence of drug-induced nephrotoxicity [J].

Coca, S ;

Perazella, MA .

AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2002, 324 (06) :342-344

[4] Renal lesions in HIV-1-positive patient treated with tenofovir [J].

Créput, C ;

Gonzalez-Canali, G ;

Hill, G ;

Piketty, C ;

Kazatchkine, M ;

Nochy, D .

AIDS, 2003, 17 (06) :935-937

[5] Development of proteinuria or elevated serum creatinine and mortality in HIV-infected women [J].

Gardner, LI ;

Holmberg, SD ;

Williamson, JM ;

Szczech, LA ;

Carpenter, CCJ ;

Rompalo, AM ;

Schuman, P ;

Klein, RS .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2003, 32 (02) :203-209

[6]

ISNARDBAGNIS C, 2002, J AM SOC NEPHROL, V13, pA448

[7] HIV-ASSOCIATED IMMUNE-MEDIATED RENAL-DISEASE [J].

KIMMEL, PL ;

PHILLIPS, TM ;

FERREIRACENTENO, A ;

FARKASSZALLASI, T ;

ABRAHAM, AA ;

GARRETT, CT .

KIDNEY INTERNATIONAL, 1993, 44 (06) :1327-1340

[8] ELECTROLYTE AND ACID-BASE-DISORDERS ASSOCIATED WITH AIDS - AN ETIOLOGIC REVIEW [J].

PERAZELLA, MA ;

BROWN, E .

JOURNAL OF GENERAL INTERNAL MEDICINE, 1994, 9 (04) :232-236

[9]

Reynes J., 2003, 10 C RETR OPP INF BO

[10] Predictors of proteinuria and renal failure among women with HIV infection [J].

Szczech, LA ;

Gange, SJ ;

van der Horst, C ;

Bartlett, JA ;

Young, M ;

Cohen, MH ;

Anastos, K ;

Klassen, PS ;

Svetkey, LP .

KIDNEY INTERNATIONAL, 2002, 61 (01) :195-202

← 1 2 →