INVASIVE BRAIN STIMULATION IN THE TREATMENT OF EPILEPSY

被引：0

作者：

Sprengers, Mathieu ^{[1
]}

Raedt, Robrecht ^{[1
]}

Meurs, Alfred ^{[1
]}

Carrette, Evelien ^{[1
]}

van Roost, Dirk ^{[2
]}

Boon, Paul ^{[1
]}

Vonck, Kristl ^{[1
]}

机构：

[1] Ghent Univ Hosp, Dept Neurol, De Pintelaan 185, B-9000 Ghent, Belgium

[2] Ghent Univ Hosp, Dept Neurosurg, B-9000 Ghent, Belgium

来源：

RECENT ADVANCES IN PREDICTING AND PREVENTING EPILEPTIC SEIZURES | 2013年

关键词：

TEMPORAL-LOBE EPILEPSY; CENTROMEDIAN THALAMIC NUCLEUS; CHRONIC ELECTRICAL-STIMULATION; HIGH-FREQUENCY STIMULATION; TERM-FOLLOW-UP; CHRONIC CEREBELLAR STIMULATION; PILOCARPINE-INDUCED SEIZURES; INTRACTABLE PARTIAL EPILEPSY; LONG-TERM; ANTERIOR NUCLEUS;

D O I：

暂无

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Invasive brain stimulation has emerged as an alternative treatment for refractory epilepsy patients and an increasing number of trials evaluating its efficacy and safety have been published. Various brain structures have been targeted, including the cerebellum, the anterior and centromedian thalamic nucleus, the hippocampus, the ictal onset zone and the subthalamic and caudate nucleus. The rationale for each of these targets and the results obtained in open-label and randomized controlled trials (RCTs) are discussed, with particular emphasis on two large RCTs that investigated open-loop anterior thalamic deep brain stimulation and responsive stimulation of the ictal onset zone. We conclude that promising results have been published for most targets, mainly in open-label trials, and that more RCTs are needed.

引用

页码：42 / 59

页数：18

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