Robustness and topology of the yeast cell cycle Boolean network

被引:9
作者
Lee, Wen-Bin [2 ]
Huang, Jiun-Yan [1 ]
机构
[1] Chung Hua Univ, Dept Bioinformat, Hsinchu 300, Taiwan
[2] Chung Hua Univ, Dept Comp Sci & Informat Engn, Hsinchu 300, Taiwan
关键词
Yeast cell cycle network; Robustness; Network topology; Boolean network; BIOLOGICAL ROBUSTNESS; BIOCHEMICAL NETWORKS; GENE NETWORKS; DYNAMICS; CANCER; DESIGN; MODELS; SYSTEM;
D O I
10.1016/j.febslet.2009.02.010
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Yeast cell cycle Boolean network was used as a case study of robustness to protein noise. Robustness was interpreted as involving stability of G1 steady state and sequence of gene expression from cell cycle START to stationary G1. A robustness measure to evaluate robustness strength of a network was proposed. Robust putative networks corresponding to the same steady state and sequence of gene expression of wild-type network were sampled. Architecture of wild-type yeast cell cycle network can be revealed by average topology pro. le of sampled robust putative networks. Crown Copyright (C) 2009 Published by Elsevier B.V. on behalf of Federation of European Biochemical society. All rights reserved.
引用
收藏
页码:927 / 932
页数:6
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