(+)-Catechin attenuates activation of hepatic stellate cells

被引：9

作者：

Braganca de Moraes, Cristina Machado ^{[1
]}

Bitencourt, Shanna ^{[1
]}

de Mesquita, Fernanda Cristina ^{[1
]}

Mello, Denizar ^{[1
]}

de Oliveira, Leticia Paranhos ^{[1
]}

da Silva, Gabriela Viegas ^{[1
]}

Lorini, Vinicius ^{[1
]}

Caberlon, Eduardo ^{[1
]}

de Souza Basso, Bruno ^{[1
]}

Schmid, Julia ^{[1
]}

Ferreira, Gabriela Acevedo ^{[1
]}

de Oliveira, Jarbas Rodrigues ^{[1
]}

机构：

[1] Pontificia Univ Catolica Rio Grande do Sul, Lab Biofis Celular & Inflamacao, Porto Alegre, RS, Brazil

来源：

CELL BIOLOGY INTERNATIONAL | 2014年 / 38卷 / 04期

关键词：

liver fibrosis; peroxisome proliferator-activated receptor gamma; catechin; type I collagen; hepatic stellate cell; inflammation; LIVER FIBROSIS; LINE; GRX; TEA;

D O I：

10.1002/cbin.10228

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

(+)-Catechin is a type of catechin present in large amounts in acai fruits and cocoa seeds. Besides its antioxidant and anti-inflammatory activities, little is known about its effects in the liver, especially during hepatic fibrosis. We report here the effects of (+)-catechin on hepatic stellate cells. (+)-Catechin induced quiescent phenotype in GRX cells, along with an increase in lipid droplets. Proliferator-activated receptor gamma mRNA expression was upregulated, whereas type I collagen mRNA expression was downregulated. Pro-inflammatory cytokines were not influenced by (+)-catechin, whereas the levels of interleukin 10 were significantly increased. The data provide evidence that (+)-catechin can reduce hepatic stellate cell activation.

引用

页码：526 / 530

页数：5

共 17 条

[11]

Kershenobich Stalnikowitz D., 2003, ANN HEPATOL, V2, P159, DOI 10.1016/S1665-2681(19

[12] Antifibrotic effects of green tea on in vitro and in vivo models of liver fibrosis [J].

Kim, Hye Kyung ;

Yang, Taik-Hoon ;

Cho, Hong-Yon .

WORLD JOURNAL OF GASTROENTEROLOGY, 2009, 15 (41) :5200-5205

[13] Inactivation of myofibroblasts during regression of liver fibrosis [J].

Kisseleva, Tatiana ;

Brenner, David A. .

CELL CYCLE, 2013, 12 (03) :381-382

[14] Cytokines and STATs in liver fibrosis [J].

Kong, Xiaoni ;

Horiguchi, Norio ;

Mori, Masatomo ;

Gao, Bin .

FRONTIERS IN PHYSIOLOGY, 2012, 3

[15] Influence of Formulation and Processing on Absorption and Metabolism of Flavan-3-Ols from Tea and Cocoa [J].

Neilson, Andrew P. ;

Ferruzzi, Mario G. .

ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 2, 2011, 2 :125-151

[16] Flavan 3-ols improve metabolic syndrome risk factors: evidence and mechanisms [J].

Osakabe, Naomi .

JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 2013, 52 (03) :186-192

[17] Extracts of Lindera obtusiloba induce antifibrotic effects in hepatic stellate cells via suppression of a TGF-β-mediated profibrotic gene expression pattern [J].

Ruehl, Martin ;

Erben, Ulrike ;

Kim, Kiyoung ;

Freise, Christian ;

Dagdelen, Tarkan ;

Eisele, Silke ;

Trowitzsch-Kienast, Wolfram ;

Zeitz, Martin ;

Jia, Jidong ;

Stickel, Felix ;

Somasundaram, Rajan .

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2009, 20 (08) :597-606

← 1 2 →