(+)-Catechin attenuates activation of hepatic stellate cells

被引：9

作者：

Braganca de Moraes, Cristina Machado ^{[1
]}

Bitencourt, Shanna ^{[1
]}

de Mesquita, Fernanda Cristina ^{[1
]}

Mello, Denizar ^{[1
]}

de Oliveira, Leticia Paranhos ^{[1
]}

da Silva, Gabriela Viegas ^{[1
]}

Lorini, Vinicius ^{[1
]}

Caberlon, Eduardo ^{[1
]}

de Souza Basso, Bruno ^{[1
]}

Schmid, Julia ^{[1
]}

Ferreira, Gabriela Acevedo ^{[1
]}

de Oliveira, Jarbas Rodrigues ^{[1
]}

机构：

[1] Pontificia Univ Catolica Rio Grande do Sul, Lab Biofis Celular & Inflamacao, Porto Alegre, RS, Brazil

来源：

CELL BIOLOGY INTERNATIONAL | 2014年 / 38卷 / 04期

关键词：

liver fibrosis; peroxisome proliferator-activated receptor gamma; catechin; type I collagen; hepatic stellate cell; inflammation; LIVER FIBROSIS; LINE; GRX; TEA;

D O I：

10.1002/cbin.10228

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

(+)-Catechin is a type of catechin present in large amounts in acai fruits and cocoa seeds. Besides its antioxidant and anti-inflammatory activities, little is known about its effects in the liver, especially during hepatic fibrosis. We report here the effects of (+)-catechin on hepatic stellate cells. (+)-Catechin induced quiescent phenotype in GRX cells, along with an increase in lipid droplets. Proliferator-activated receptor gamma mRNA expression was upregulated, whereas type I collagen mRNA expression was downregulated. Pro-inflammatory cytokines were not influenced by (+)-catechin, whereas the levels of interleukin 10 were significantly increased. The data provide evidence that (+)-catechin can reduce hepatic stellate cell activation.

引用

页码：526 / 530

页数：5

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