Heterogeneity of tumor-infiltrating myeloid cells in era of single-cell genomics

被引:15
作者
Chu, Xiaojing [1 ]
Zhang, Yu [1 ]
Cheng, Sijin [1 ]
机构
[1] Changping Lab, Beijing 102206, Peoples R China
关键词
Single-cell genomics; tumor-infiltrating myeloid cells; tumor microenvironment; tumor immunotherapy; DENDRITIC CELLS; MAST-CELLS; CANCER-IMMUNOTHERAPY; IMMUNE LANDSCAPE; RESPONSES; SURVIVAL;
D O I
10.21147/j.issn.1000-9604.2022.06.01
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Tumor microenvironment (TME) is highly heterogeneous and composed of complex cellular components, including multiple kinds of immune cells. Among all immune cells in TME, tumor-infiltrating myeloid cells (TIMs) account for a large proportion and play roles as key regulators in a variety of functions, ranging from immune-mediated tumor killing to tumor immune evasion. Understanding the heterogeneity of TIMs will provide valuable insights for new therapeutic targeting of myeloid cells. Single-cell genomic technologies deciphering cell composition and gene expression at single-cell resolution have largely improved our understanding of the cellular heterogeneity of TIMs and highlighted several novel cell subtypes contributing to the variation of patient survival and treatment response. However, these cell subtypes were defined based on limited data without a concordant nomenclature, which makes it difficult to understand whether they exist in different studies. Thus, in this review, we comprehensively summarized the common agreements and current different opinions on the heterogeneity of TIMs gained from single-cell studies; evaluated the feasibility of current myeloid cell targets at single-cell level and proposed a uniform nomenclature for TIM subsets.
引用
收藏
页码:543 / 553
页数:12
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