Synthesis, Discovery, and Quantitation of Dihomo-Isofurans: Biomarkers for In Vivo Adrenic Acid Peroxidation

被引：36

作者：

de La Torre, Aurelien ^{[1
,2
]}

Lee, Yiu Yiu

Oger, Camille ^{[1
,2
]}

Sangild, Per Torp ^{[4
]}

Durand, Thierry ^{[1
,2
]}

Lee, Jetty Chung-Yung ^{[3
]}

Galano, Jean-Marie ^{[1
,2
]}

机构：

[1] Univ Montpellier I, IBMM, CNRS, UMR 5247, F-34093 Montpellier 05, France

[2] Univ Montpellier 2, Fac Pharm, ENSCM, F-34093 Montpellier 05, France

[3] Univ Hong Kong, Sch Biol Sci, Hong Kong, Hong Kong, Peoples R China

[4] Univ Copenhagen, Fac Sci, Dept Nutr Exercise & Sports, Frederiksberg, Denmark

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 24期

关键词：

biomarkers; lipids; mass spectrometry; oxidation; total synthesis; OXIDIZED LIPID PRODUCTS; OXIDATIVE STRESS; DOCOSAHEXAENOIC ACID; PREFRONTAL CORTEX; CEREBRAL-CORTEX; OXYGEN-TENSION; WHITE-MATTER; METABOLITES; CYCLIZATION; DISEASE;

D O I：

10.1002/anie.201402440

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The growing importance of lipidomics, and the interest of non-enzymatic metabolites of polyunsaturated fatty acids (PUFAs) prompted us to initiate the synthesis of novel dihomo-IsoF compounds. Such metabolites of adrenic acid, the main PUFA in white matter, were synthesized using a divergent approach based on an orthoester cyclization. LC-MS/MS investigation on pig brains showed the potential of this novel biomarker for the first time, as a powerful new tool for brain lipid peroxidation assessment.

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收藏

页码：6249 / 6252

页数：4

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