Prospective Study on the Efficacy and Safety of Antibiotics for Treating Patients with Acute Appendicitis (NOTA) Non Operative Treatment of Acute Appendicitis

Background: In surgical practices, the commonest acute condition is seen to be the acute appendicitis. The appendectomy being the well-known surgical treatment of appendicitis is also linked to all complications of surgery. Aim: To assess efficacy and safety of antibiotic treatment in patients with acute appendicitis. Methods: This observational prospective cohort study was conducted on 150 patients with right lower abdominal pain and diagnosed cases of acute appendicitis. All the patients >15years of age with acute appendicitis after full filling inclusion/exclusion criteria were included. Results: A total of 150 patients were recruited for this study. There were a total of 105(70%) females and 45(30%) were male. The NOTA failure rate was observed in short term (<7days) and reported in 18(12%) patients, out of these patients 12(66.7%) failed NOTA with antibiotics as having probable appendicitis at admission, and 6(33.3%) had equivocal acute appendicitis. No reoccurrence was reported within 15 days in cases with initial failure and then operated within seven days. Of these patients almost 15(10%) recurrence episodes were recorded in 6 months follow-up. Ten were treated successfully with the further antibiotics cycles. Only 4 further recurrences were observed at one-year time. Conclusion: The appropriate addressing of the treatment to the cases of acute appendicitis from the initial evaluation and diagnosis; antibiotic treatment will be safer and effective.