Synthesis, Characterization and Antimicrobial Evaluation of Some New Heterocycles Incorporating Phenothiazine Moiety

被引：6
|
作者：
Bayoumy, Nesma M. [1 ]
Fekri, Ahmed [2 ]
Tawfik, Eman H. [2 ,3 ]
Fadda, Ahmed A. [2 ]
机构：
[1] Delta Univ Sci & Technol, Fac Oral & Dent Med, Dent Biomat Dept, Mansoura, Egypt
[2] Mansoura Univ, Dept Chem, Fac Sci, Mansoura, Egypt
[3] Taibah Univ, Fac Sci & Arts, Dept Chem, Ulla, Saudi Arabia
来源：
POLYCYCLIC AROMATIC COMPOUNDS | 2021年 / 41卷 / 05期
关键词：
Antimicrobial activity; bifunctional reagents; heterocycles; phenothiazine; RESISTANT MYCOBACTERIUM-TUBERCULOSIS;
D O I：
10.1080/10406638.2019.1636832
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Innovative multiple heterocyclic rings incorporating phenothiazine moiety (2-16) were synthesized through the reaction of N-cyanoacetamide phenothiazine derivative (2) with various types of reagents. The new compounds were tested against their antimicrobial activity. Compounds 10, 14, 15 and 16 showed higher activity toward Gram (+) than Gram (-) bacteria strains. Spectral and analytical data confirmed the correct structures of all the compounds.
引用
收藏
页码：982 / 991
页数：10
相关论文
共 50 条
  • [41] Synthesis and Microbiological Evaluation of Some New Phenothiazine Derivatives
    Sen, Sandip
    De, Biplab
    Mallik, Arunabha
    Roy, Biswabara
    Kumar, Deepak
    INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2018, 28 (02) : 221 - 226
  • [42] Synthesis, characterization, and pharmacological evaluation of some novel thiadiazoles and thiazoles incorporating pyrazole moiety as anticancer agents
    Sobhi M. Gomha
    Taher A. Salah
    Abdou O. Abdelhamid
    Monatshefte für Chemie - Chemical Monthly, 2015, 146 : 149 - 158
  • [43] Synthesis, characterization, and pharmacological evaluation of some novel thiadiazoles and thiazoles incorporating pyrazole moiety as anticancer agents
    Gomha, Sobhi M.
    Salah, Taher A.
    Abdelhamid, Abdou O.
    MONATSHEFTE FUR CHEMIE, 2015, 146 (01): : 149 - 158
  • [44] Synthesis, Antibacterial, and Antiviral Evaluation of New Heterocycles Containing the Pyridine Moiety
    Salem, Marwa S.
    Sakr, Sameh I.
    El-Senousy, Waled M.
    Madkour, Hassan M. F.
    ARCHIV DER PHARMAZIE, 2013, 346 (10) : 766 - 773
  • [45] Synthesis and in vitro biological evaluation of new heterocycles based on the indole moiety
    Kandile, Nadia G.
    Mohamed, Mansoura I.
    Ismaeel, Hind M.
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2015, 30 (01) : 140 - 151
  • [46] Synthesis, reaction, antimicrobial, and docking study of new chalcones incorporating isoquinoline moiety
    Mukhtar, Shorouk S.
    Saleh, Fatma M.
    Hassaneen, Hamdi M.
    Hafez, Taghrid S.
    Hassan, Ashraf S.
    Morsy, Nesrin M.
    Teleb, Mohamed A. Mohamed
    SYNTHETIC COMMUNICATIONS, 2022, 52 (19-20) : 1909 - 1916
  • [47] Synthesis and antimicrobial activities evaluation of some new thiadiazinone and thiadiazepinone derivatives bearing sulfonamide moiety
    Dalloul, Hany M. M.
    El-Nwairy, Khaled A.
    Shorafa, Ali Z.
    Abu Samaha, Ahmed S.
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2018, 193 (05) : 288 - 293
  • [48] Synthesis and Biological Evaluation of Some New Amide Moiety Bearing Quinoxaline Derivatives as Antimicrobial Agents
    Abu Mohsen, U.
    Yurttas, L.
    Acar, U.
    Ozkay, Y.
    Kaplancikli, Z. A.
    Gencer, H. Karaca
    Canturk, Z.
    DRUG RESEARCH, 2015, 65 (05) : 266 - 271
  • [49] Synthesis and Antioxidant Activity of Some New Binary Pyrazoles Containing Core Phenothiazine Moiety
    Hamama, Wafaa S.
    Gouda, Moustafa A.
    El-din, Hadwah A. Kamal
    Zoorob, Hanafi H.
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2017, 54 (02) : 1369 - 1377
  • [50] Synthesis of Novel Heterocycles Comprising Benzothiazole Moiety and Their Antimicrobial Evaluations
    Mohamed, Khaled S.
    Elbialy, Engy E.
    Fadda, Ahmed A.
    POLYCYCLIC AROMATIC COMPOUNDS, 2022, 42 (08) : 5585 - 5598
12345