Synthesis, Characterization and Antimicrobial Evaluation of Some New Heterocycles Incorporating Phenothiazine Moiety

被引：6

作者：

Bayoumy, Nesma M. ^{[1
]}

Fekri, Ahmed ^{[2
]}

Tawfik, Eman H. ^{[2
,3
]}

Fadda, Ahmed A. ^{[2
]}

机构：

[1] Delta Univ Sci & Technol, Fac Oral & Dent Med, Dent Biomat Dept, Mansoura, Egypt

[2] Mansoura Univ, Dept Chem, Fac Sci, Mansoura, Egypt

[3] Taibah Univ, Fac Sci & Arts, Dept Chem, Ulla, Saudi Arabia

来源：

POLYCYCLIC AROMATIC COMPOUNDS | 2021年 / 41卷 / 05期

关键词：

Antimicrobial activity; bifunctional reagents; heterocycles; phenothiazine; RESISTANT MYCOBACTERIUM-TUBERCULOSIS;

D O I：

10.1080/10406638.2019.1636832

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Innovative multiple heterocyclic rings incorporating phenothiazine moiety (2-16) were synthesized through the reaction of N-cyanoacetamide phenothiazine derivative (2) with various types of reagents. The new compounds were tested against their antimicrobial activity. Compounds 10, 14, 15 and 16 showed higher activity toward Gram (+) than Gram (-) bacteria strains. Spectral and analytical data confirmed the correct structures of all the compounds.

引用

页码：982 / 991

页数：10

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