Synthesis, Characterization and Antimicrobial Evaluation of Some New Heterocycles Incorporating Phenothiazine Moiety

被引：6
|
作者：
Bayoumy, Nesma M. [1 ]
Fekri, Ahmed [2 ]
Tawfik, Eman H. [2 ,3 ]
Fadda, Ahmed A. [2 ]
机构：
[1] Delta Univ Sci & Technol, Fac Oral & Dent Med, Dent Biomat Dept, Mansoura, Egypt
[2] Mansoura Univ, Dept Chem, Fac Sci, Mansoura, Egypt
[3] Taibah Univ, Fac Sci & Arts, Dept Chem, Ulla, Saudi Arabia
来源：
POLYCYCLIC AROMATIC COMPOUNDS | 2021年 / 41卷 / 05期
关键词：
Antimicrobial activity; bifunctional reagents; heterocycles; phenothiazine; RESISTANT MYCOBACTERIUM-TUBERCULOSIS;
D O I：
10.1080/10406638.2019.1636832
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Innovative multiple heterocyclic rings incorporating phenothiazine moiety (2-16) were synthesized through the reaction of N-cyanoacetamide phenothiazine derivative (2) with various types of reagents. The new compounds were tested against their antimicrobial activity. Compounds 10, 14, 15 and 16 showed higher activity toward Gram (+) than Gram (-) bacteria strains. Spectral and analytical data confirmed the correct structures of all the compounds.
引用
收藏
页码：982 / 991
页数：10
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