Association between IL-4-589C>T polymorphism and colorectal cancer risk

被引：4
作者：
Li, Qiang [1 ]
Wang, Qian [2 ]
Xu, Xiaoyan [3 ]
Ren, Songtao [4 ]
Wang, Li [5 ]
机构：
[1] Liaocheng Peoples Hosp, Proctol Dept, Liaocheng City 252000, Shandong, Peoples R China
[2] Liaocheng Peoples Hosp, Ultrasonog Dept, Liaocheng City 252000, Shandong, Peoples R China
[3] Liaocheng Peoples Hosp, Dept Neurol, Liaocheng City 252000, Shandong, Peoples R China
[4] Liaocheng Peoples Hosp, Dept Neurosurg, Liaocheng City 252000, Shandong, Peoples R China
[5] Liaocheng Peoples Hosp, Dept Obstet & Gynaecol, Liaocheng City 252000, Shandong, Peoples R China
来源：
TUMOR BIOLOGY | 2014年 / 35卷 / 03期
关键词：
Colorectal cancer; Interleukin-4; Meta-analysis; Risk; GENE POLYMORPHISMS; PROSTATE-CANCER; EXPRESSION; INTERLEUKIN-4; INFLAMMATION; MECHANISMS; SMOKING; NUCB2;
D O I：
10.1007/s13277-013-1352-4
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In order to make a comprehensive assessment of the potential association between interleukin-4 (IL-4) -589C > T and colorectal cancer (CRC) susceptibility, we conducted a meta-analysis of six epidemiological studies, which included 1,317 CRC patients and 1,659 controls. The data showed that IL-4 -589C > T was not associated with increased CRC risk in the overall population. In the subgroup analysis of IL-4 -589C > T, the results did not change when the analyses were restricted to race. Based on this meta-analysis, we conclude that IL-4 -589C > T may be not a risk factor for CRC development. Further research is needed to assess possible gene-gene or gene-environment-lifestyle interactions on CRC.
引用
收藏
页码：2675 / 2679
页数：5
相关论文
共 36 条
  • [1] Synergistic induction of apoptosis and chemosensitization of human colorectal cancer cells by histone deacetylase inhibitor, scriptaid, and proteasome inhibitors: potential mechanisms of action
    Abaza, M. S. I.
    Bahman, A. M.
    Al-Attiyah, R. J.
    Kollamparambil, A. M.
    [J]. TUMOR BIOLOGY, 2012, 33 (06) : 1951 - 1972
  • [2] Chronic inflammation, immunosuppression and cancer: New insights and outlook
    Baniyash, M
    [J]. SEMINARS IN CANCER BIOLOGY, 2006, 16 (01) : 80 - 88
  • [3] Evaluation of antigen specific recognition and cell mediated cytotoxicity by a modified lysispot assay in a rat colon carcinoma model
    Bordignon, Valentina
    Cordiali-Fei, Paola
    Rinaldi, Monica
    Signori, Emanuela
    Cottarelli, Andrea
    Zonfrillo, Manuela
    Ensoli, Fabrizio
    Rasi, Guido
    Fuggetta, Maria Pia
    [J]. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2012, 31
  • [4] Cigarette Smoking, Genetic Variants in Carcinogen-metabolizing Enzymes, and Colorectal Cancer Risk
    Cleary, Sean P.
    Cotterchio, Michelle
    Shi, Ellen
    Gallinger, Steven
    Harper, Patricia
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 2010, 172 (09) : 1000 - 1014
  • [5] Increased expression of CD133 and reduced dystroglycan expression are strong predictors of poor outcome in colon cancer patients
    Coco, Claudio
    Zannoni, Gian Franco
    Caredda, Emanuele
    Sioletic, Stefano
    Boninsegna, Alma
    Migaldi, Mario
    Rizzo, Gianluca
    Bonetti, Luca Reggiani
    Genovese, Giannicola
    Stigliano, Egidio
    Cittadini, Achille
    Sgambato, Alessandro
    [J]. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2012, 31
  • [6] High incidence of CTLA-4 AA (CT60) polymorphism in renal cell cancer
    Cozar, Jose M.
    Romero, Jose M.
    Aptsiauri, Natalia
    Vazquez, Fernando
    Vilchez, Jose R.
    Tallada, Miguel
    Garrido, Federico
    Ruiz-Cabello, Francisco
    [J]. HUMAN IMMUNOLOGY, 2007, 68 (08) : 698 - 704
  • [7] Estimates of cancer incidence and mortality in Europe in 2008
    Ferlay, J.
    Parkin, D. M.
    Steliarova-Foucher, E.
    [J]. EUROPEAN JOURNAL OF CANCER, 2010, 46 (04) : 765 - 781
  • [8] Functional protease profiling with reporter peptides in serum specimens of colorectal cancer patients: demonstration of its routine diagnostic applicability
    Findeisen, Peter
    Costina, Victor
    Yepes, Diego
    Hofheinz, Ralf
    Neumaier, Michael
    [J]. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2012, 31
  • [9] Inflammation-related gene polymorphisms and colorectal adenoma
    Gunter, Marc J.
    Canzian, Federico
    Landi, Stefano
    Chanock, Stephen J.
    Sinha, Rashmi
    Rothman, Nathaniel
    [J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2006, 15 (06) : 1126 - 1131
  • [10] Characterization of Gene-Environment Interactions for Colorectal Cancer Susceptibility Loci
    Hutter, Carolyn M.
    Chang-Claude, Jenny
    Slattery, Martha L.
    Pflugeisen, Bethann M.
    Lin, Yi
    Duggan, David
    Nan, Hongmei
    Lemire, Mathieu
    Rangrej, Jagadish
    Figueiredo, Jane C.
    Jiao, Shuo
    Harrison, Tabitha A.
    Liu, Yan
    Chen, Lin S.
    Stelling, Deanna L.
    Warnick, Greg S.
    Hoffmeister, Michael
    Kuery, Sebastien
    Fuchs, Charles S.
    Giovannucci, Edward
    Hazra, Aditi
    Kraft, Peter
    Hunter, David J.
    Gallinger, Steven
    Zanke, Brent W.
    Brenner, Hermann
    Frank, Bernd
    Ma, Jing
    Ulrich, Cornelia M.
    White, Emily
    Newcomb, Polly A.
    Kooperberg, Charles
    LaCroix, Andrea Z.
    Prentice, Ross L.
    Jackson, Rebecca D.
    Schoen, Robert E.
    Chanock, Stephen J.
    Berndt, Sonja I.
    Hayes, Richard B.
    Caan, Bette J.
    Potter, John D.
    Hsu, Li
    Bezieau, Stephane
    Chan, Andrew T.
    Hudson, Thomas J.
    Peters, Ulrike
    [J]. CANCER RESEARCH, 2012, 72 (08) : 2036 - 2044
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