The use of DNA methylation clock in aging research

被引：18

作者：

He, Xi ^{[1
,2
]}

Liu, Jiaojiao ^{[1
,2
]}

Liu, Bo ^{[1
,2
]}

Shi, Jingshan ^{[1
,2
]}

机构：

[1] Zunyi Med Univ, Minist Educ, Key Lab Basic Pharmacol, Zunyi 563003, Guizhou, Peoples R China

[2] Zunyi Med Univ, Joint Int Res Lab Ethnomed, Minist Educ, Zunyi 563003, Guizhou, Peoples R China

来源：

EXPERIMENTAL BIOLOGY AND MEDICINE | 2021年 / 246卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Aging; DNA methylation; epigenetic; clock; intervention; EPIGENETIC AGE ACCELERATION; ALL-CAUSE MORTALITY; BIOLOGICAL AGE; HUMAN TISSUES; CANCER-RISK; HUMAN BRAIN; LIFE-SPAN; BLOOD; PREDICTOR; ASSOCIATIONS;

D O I：

10.1177/1535370220968802

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

One of the key characteristics of aging is a progressive loss of physiological integrity, which weakens bodily functions and increases the risk of death. A robust biomarker is important for the assessment of biological age, the rate of aging, and a person's health status. DNA methylation clocks, novel biomarkers of aging, are composed of a group of cytosine-phosphate-guanine dinucleotides, the DNA methylation status of which can be used to accurately measure subjective age. These clocks are considered accurate biomarkers of chronological age for humans and other vertebrates. Numerous studies have demonstrated these clocks to quantify the rate of biological aging and the effects of longevity and anti-aging interventions. In this review, we describe the purpose and use of DNA methylation clocks in aging research.

引用

页码：436 / 446

页数：11

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