Synthesis of 16α-[18F]fluoroestradiol-3,17β-disulphamate

被引：0

作者：

Römer, J ^{[1
]}

Füchtner, F ^{[1
]}

Steinbach, J ^{[1
]}

机构：

[1] Forschungszentrum Rossendorf EV, Inst Bioorgan & Radiopharmaceut Chem, D-01314 Dresden, Germany

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2000年 / 43卷 / 05期

关键词：

16 alpha-[F-18]fluoroestradiol-3,17 beta-disulphamate; F-18-labelled tracer; positron emission tomography; sulphamoylation; HPLC purification;

D O I：

暂无

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of 16 alpha-[F-18]fluoroestradiol-3,17 beta-disulphamate ([F-18]FESDS) is described. 16-alpha[F-18]Fluoroestradiol ([F-18]FES) is converted using excess sulphamoyl chloride in absolute acetonitrile in the presence of Kryptofix 2.2.2 and potassium carbonate using an automatically operating module. The required time for the synthesis related to end of bombardment is 3h, the maximum yield is 6%, and the maximum decay-corrected yield is 20%. The radiochemical purity of [F-18]FESDS is > 99%. The specific radioactivity of [F-18]FESDS is found to be between 150 and 200 GBq/mu mol.

引用

页码：425 / 436

页数：12

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