Metal-free decarboxylative acylation of isoquinolines using α-keto acids in water

被引：23

作者：

Chaubey, Narendra R. ^{[1
]}

Singh, Krishna Nand ^{[1
]}

机构：

[1] Banaras Hindu Univ, Inst Sci, Dept Chem, Ctr Adv Study, Varanasi 221005, Uttar Pradesh, India

来源：

TETRAHEDRON LETTERS | 2017年 / 58卷 / 24期

关键词：

Acylation; Benzoylation; Metal-free; Isoquinolines; Radicals; Keto acids; TERTIARY-AMINES; N-HETEROCYCLES; COUPLING REACTION; ALDEHYDES; ACTIVATION; AMIDES; BONDS;

D O I：

10.1016/j.tetlet.2017.04.098

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient method for acylation of isoquinolines has been developed using alpha-ketoacids under metal-and additive-free conditions in water. The protocol involves C(sp(2))-H functionalization of isoquinolines providing an easy access to C1-benzoylated isoquinolines, which constitute the core structure of a number of biological active compounds and serve as key intermediate in the synthesis of many alkaloids. (C) 2017 Elsevier Ltd. All rights reserved.

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收藏

页码：2347 / 2350

页数：4

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