Metal-free decarboxylative acylation of isoquinolines using α-keto acids in water

被引：23
|
作者：
Chaubey, Narendra R. [1 ]
Singh, Krishna Nand [1 ]
机构：
[1] Banaras Hindu Univ, Inst Sci, Dept Chem, Ctr Adv Study, Varanasi 221005, Uttar Pradesh, India
来源：
TETRAHEDRON LETTERS | 2017年 / 58卷 / 24期
关键词：
Acylation; Benzoylation; Metal-free; Isoquinolines; Radicals; Keto acids; TERTIARY-AMINES; N-HETEROCYCLES; COUPLING REACTION; ALDEHYDES; ACTIVATION; AMIDES; BONDS;
D O I：
10.1016/j.tetlet.2017.04.098
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient method for acylation of isoquinolines has been developed using alpha-ketoacids under metal-and additive-free conditions in water. The protocol involves C(sp(2))-H functionalization of isoquinolines providing an easy access to C1-benzoylated isoquinolines, which constitute the core structure of a number of biological active compounds and serve as key intermediate in the synthesis of many alkaloids. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2347 / 2350
页数：4
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