vesl, a gene encoding VASP/Ena family related protein, is upregulated during seizure, long-term potentiation and synaptogenesis

被引：251

作者：

Kato, A ^{[1
]}

Ozawa, F ^{[1
]}

Saitoh, Y ^{[1
]}

Hirai, K ^{[1
]}

Inokuchi, K ^{[1
]}

机构：

[1] MITSUBISHI KASEI INST LIFE SCI,MACHIDA,TOKYO 194,JAPAN

来源：

FEBS LETTERS | 1997年 / 412卷 / 01期

关键词：

long-term potentiation; seizure; hippocampus; gene regulation; PCR differential display;

D O I：

10.1016/S0014-5793(97)00775-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have isolated a novel cDNA, vesl, that was induced during convulsive seizure in the rat hippocampus. The vesl gene encodes a protein of 186 amino acids that has significant homology to the EVH1 domain of the VASP/Ena family of proteins implicated in the control of microfilament dynamics. The expression of vesl mRNA was induced in the granule cell layer during persistent long-term potentiation (LTP) of the dentate gyrus in an NMDA receptor-dependent manner. Furthermore, vesl mRNA was expressed at a high level during hippocampal synaptogenesis. We suggest that the Vesl protein may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. (C) 1997 Federation of European Biochemical Societies.

引用

页码：183 / 189

页数：7

共 37 条

[1] CORRELATIONS BETWEEN IMMEDIATE-EARLY GENE INDUCTION AND THE PERSISTENCE OF LONG-TERM POTENTIATION [J].